tolerance

  • Open Access
    Butyrate Producers as Potential Next-Generation Probiotics: Safety Assessment of the Administration of <em>Butyricicoccus pullicaecorum</em> to Healthy Volunteers
    Research Article | Host-Microbe Biology
    Butyrate Producers as Potential Next-Generation Probiotics: Safety Assessment of the Administration of Butyricicoccus pullicaecorum to Healthy Volunteers

    This study is the first to determine the safety and tolerance in humans of a butyrate-producing Clostridium cluster IV next-generation probiotic. Advances in gut microbiota research have triggered interest in developing colon butyrate producers as next-generation probiotics. Butyricicoccus pullicaecorum...

    Leen Boesmans, Mireia Valles-Colomer, Jun Wang, Venessa Eeckhaut, Gwen Falony, Richard Ducatelle, Filip Van Immerseel, Jeroen Raes, Kristin Verbeke
  • Open Access
    Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling
    Research Article | Host-Microbe Biology
    Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling

    While the ability for humans to host a complex microbial ecosystem is an essential property of life, the mechanisms allowing for immune tolerance of such a large microbial load are not completely understood and are currently the focus of intense research. This study shows that an important proinflammatory pathway that is commonly triggered by pathogenic bacteria upon interaction with the host is, in fact, actively repressed by the...

    Eva d’Hennezel, Sahar Abubucker, Leon O. Murphy, Thomas W. Cullen
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