statistics
Special Issue Perspective | Therapeutics and PreventionRigorous Statistical Methods for Rigorous Microbiome ScienceHigh-throughput sequencing has facilitated discovery in microbiome science, but distinguishing true discoveries from spurious signals can be challenging. The Statistical Diversity Lab develops rigorous statistical methods and statistical software for the analysis of microbiome and biodiversity data.
Research Article | Novel Systems Biology TechniquesDiscrete False-Discovery Rate Improves Identification of Differentially Abundant MicrobesDS-FDR can achieve higher statistical power to detect significant findings in sparse and noisy microbiome data compared to the commonly used Benjamini-Hochberg procedure and other FDR-controlling procedures.
Research Article | Host-Microbe BiologyDevelopment of Inflammatory Bowel Disease Is Linked to a Longitudinal Restructuring of the Gut Metagenome in MiceIBD patients harbor distinct microbial communities with functional capabilities different from those seen with healthy people. But is this cause or effect? Answering this question requires data on changes in gut microbial communities leading to disease onset. By performing weekly metagenomic sequencing and mixed-effects modeling on an established mouse model of IBD, we identified several functional pathways encoded by the gut microbiome...