regulatory network
Research Article | Molecular Biology and PhysiologyFrom Modules to Networks: a Systems-Level Analysis of the Bacitracin Stress Response in Bacillus subtilisAntibiotic resistance poses a major threat to global health, and systematic studies to understand the underlying resistance mechanisms are urgently needed. Although significant progress has been made in deciphering the mechanistic basis of individual resistance determinants, many bacterial species rely on the induction of a whole battery of resistance modules, and the complex regulatory networks controlling these modules in response to...
Editor's Pick Research Article | Ecological and Evolutionary ScienceUnique Patterns and Biogeochemical Relevance of Two-Component Sensing in Marine BacteriaMarine microbes must manage variation in their chemical, physical, and biological surroundings. Because they directly link bacterial physiology to environmental changes, TCS systems are crucial to the bacterial cell. This study surveyed TCS systems in a large number of marine bacteria and identified key phylogenetic and lifestyle patterns in environmental sensing. We found evidence that, in comparison with bacteria as a whole, marine...
Special Issue Perspective | Molecular Biology and PhysiologyEngineering Complexity in Bacterial Regulatory Circuits for Biotechnological ApplicationsEngineering microbial systems allows the generation of new technologies having significant impact in the biotechnological industry and on human health. In the past few years, several synthetic biology approaches have been implemented in bacteria to allow precise engineering of novel regulatory circuits for several applications.