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persisters

  • Open Access
    PerSort Facilitates Characterization and Elimination of Persister Subpopulation in Mycobacteria
    Research Article | Novel Systems Biology Techniques
    PerSort Facilitates Characterization and Elimination of Persister Subpopulation in Mycobacteria

    Mycobacterium tuberculosis (MTB) persists and survives antibiotic treatments by generating phenotypically heterogeneous drug-tolerant subpopulations. The surviving cells, persisters, are a major barrier to the relapse-free treatment of tuberculosis (TB), which is already killing >1.8 million people every year and becoming deadlier with the emergence of multidrug-...

    Vivek Srinivas, Mario L. Arrieta-Ortiz, Amardeep Kaur, Eliza J. R. Peterson, Nitin S. Baliga
  • Open Access
    Proteomic Study of the Survival and Resuscitation Mechanisms of Filamentous Persisters in an Evolved <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Population from Cyclic Ampicillin Treatment
    Research Article | Molecular Biology and Physiology
    Proteomic Study of the Survival and Resuscitation Mechanisms of Filamentous Persisters in an Evolved Escherichia coli Population from Cyclic Ampicillin Treatment

    Persisters are a subpopulation of cells with enhanced survival toward antibiotic treatment and have the ability to resume normal growth when the antibiotic stress is lifted. Although proteomics is the most suitable tool to study them from a system-level perspective, the number of persisters that present naturally is too few for proteomics analysis, and thus the complex mechanisms through which they are able to survive antibiotic...

    Jordy Evan Sulaiman, Henry Lam
  • Open Access
    Extreme Antibiotic Persistence via Heterogeneity-Generating Mutations Targeting Translation
    Research Article | Novel Systems Biology Techniques
    Extreme Antibiotic Persistence via Heterogeneity-Generating Mutations Targeting Translation

    Bacterial persistence is a fascinating phenomenon in which a small subpopulation of bacteria becomes phenotypically tolerant to lethal antibiotic exposure. There is growing evidence that populations of bacteria in chronic clinical infections develop a hyperpersistent phenotype, enabling a substantially larger subpopulation to survive repeated antibiotic treatment. The mechanisms of persistence and modes of increasing persistence rates...

    Anupama Khare, Saeed Tavazoie
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