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obesity

  • Open Access
    A Metagenomic Meta-analysis Reveals Functional Signatures of Health and Disease in the Human Gut Microbiome
    Research Article | Host-Microbe Biology
    A Metagenomic Meta-analysis Reveals Functional Signatures of Health and Disease in the Human Gut Microbiome

    The composition of the gut microbiome associates with a wide range of human diseases, but the mechanisms underpinning these associations are not well understood. To shift toward a mechanistic understanding, we integrated distinct metagenomic data sets to identify functions encoded in the gut microbiome that associate with multiple diseases, which may be important to human health. Additionally, we identified functions that associate with...

    Courtney R. Armour, Stephen Nayfach, Katherine S. Pollard, Thomas J. Sharpton
  • Open Access
    Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics
    Special Issue Perspective | Therapeutics and Prevention
    Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics

    Over the past 10 years, microbiome research has focused on defining the structures associated with different disease states in multiple systems, but has fallen short on showing causation. Prior omic studies have generated many new hypotheses, but moving forward we need to start dissecting the function of each bacterium alone and in concert with complex bacterial communities in well-characterized systems.

    Casey M. Theriot
  • Open Access
    Individualized Responses of Gut Microbiota to Dietary Intervention Modeled in Humanized Mice
    Editor's Pick Observation | Host-Microbe Biology
    Individualized Responses of Gut Microbiota to Dietary Intervention Modeled in Humanized Mice

    Dietary modification has long been used empirically to modify symptoms in inflammatory bowel disease, irritable bowel syndrome, and a diverse group of diseases with gastrointestinal symptoms. There is both anecdotal and scientific evidence to suggest that individuals respond quite differently to similar dietary changes, and the highly individualized nature of the gut microbiota makes it a prime candidate for these differences. To...

    Samuel A. Smits, Angela Marcobal, Steven Higginbottom, Justin L. Sonnenburg, Purna C. Kashyap
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