metabolome
Commentary | Host-Microbe BiologyCrowdsourcing Our National GutThe microbes of the human intestinal tract play a profound role in our health. The complex interactions between our gut microbial communities and the external environment, and the resulting functional consequences, can be difficult to disentangle.
Special Issue Perspective | Host-Microbe BiologyCan Diet Influence Our Health by Altering Intestinal Microbiota-Derived Fecal Metabolites?The human gastrointestinal tract harbors a diverse, highly mutualistic microbial flora which could produce a myriad of specialized metabolites. These specialized metabolites are the chemical cellphones that gut microflora use to communicate with their human host and could potentially be used to cure diseases.
Special Issue Perspective | Host-Microbe BiologyRole of the Gut Microbiome in Vertebrate EvolutionDarwin referred to life as a struggle. Organisms compete for limited resources in nature, and their traits influence the outcome.
Special Issue Perspective | Therapeutics and PreventionBeyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized TherapeuticsOver the past 10 years, microbiome research has focused on defining the structures associated with different disease states in multiple systems, but has fallen short on showing causation. Prior omic studies have generated many new hypotheses, but moving forward we need to start dissecting the function of each bacterium alone and in concert with complex bacterial communities in well-characterized systems.
Editor's Pick Research Article | Host-Microbe BiologyMulti-omics Analysis of Periodontal Pocket Microbial Communities Pre- and PosttreatmentPeriodontal disease affects the majority of adults worldwide and has been linked to numerous systemic diseases. Despite decades of research, the reasons for the substantial differences among periodontitis patients in disease incidence, progressivity, and response to treatment remain poorly understood. While deep sequencing of oral bacterial communities has greatly expanded our comprehension of the microbial diversity of periodontal...
Editor's Pick Research Article | Host-Microbe BiologyIntegrated Role of Bifidobacterium animalis subsp. lactis Supplementation in Gut Microbiota, Immunity, and Metabolism of Infant Rhesus MonkeysProbiotics are becoming increasingly popular due to their perceived effects on health, despite a lack of mechanistic information on how they impart these benefits. Infant formula and complementary foods are common targets for supplementation with probiotics. However, different probiotic strains have different properties, and there is a lack of data on long-term health effects on the consumer. Given the increasing interest in...
Research Article | Novel Systems Biology TechniquesFrom Sample to Multi-Omics Conclusions in under 48 HoursPolymicrobial infections are difficult to diagnose due to the challenge in comprehensively cultivating the microbes present. Omics methods, such as 16S rRNA sequencing, metagenomics, and metabolomics, can provide a more complete picture of a microbial community and its metabolite production, without the biases and selectivity of microbial culture. However, these advanced methods have not been applied to clinical or industrial...
Methods and Protocols | Novel Systems Biology Techniquescual-id: Globally Unique, Correctable, and Human-Friendly Sample Identifiers for Comparative Omics StudiesThe adoption of identifiers that are globally unique, correctable, and easily handwritten or manually entered into a computer will be a major step forward for sample tracking in comparative omics studies. As the fields transition to more-centralized sample management, for example, across labs within an institution, across projects funded under a common program, or in systems designed to facilitate meta- and/or integrated analysis,...