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lactate

  • Open Access
    Pivotal Roles for pH, Lactate, and Lactate-Utilizing Bacteria in the Stability of a Human Colonic Microbial Ecosystem
    Research Article | Molecular Biology and Physiology
    Pivotal Roles for pH, Lactate, and Lactate-Utilizing Bacteria in the Stability of a Human Colonic Microbial Ecosystem

    Lactate is formed by many species of colonic bacteria, and can accumulate to high levels in the colons of inflammatory bowel disease subjects. Conversely, in healthy colons lactate is metabolized by lactate-utilizing species to the short-chain fatty acids butyrate and propionate, which are beneficial for the host. Here, we investigated the impact of continuous lactate infusions (up to 20 mM) at two pH values (6.5 and 5.5) on human...

    Shui Ping Wang, Luis A. Rubio, Sylvia H. Duncan, Gillian E. Donachie, Grietje Holtrop, Galiana Lo, Freda M. Farquharson, Josef Wagner, Julian Parkhill, Petra Louis, Alan W. Walker, Harry J. Flint
  • Open Access
    The Microbiome-Mitochondrion Connection: Common Ancestries, Common Mechanisms, Common Goals
    Perspective | Host-Microbe Biology
    The Microbiome-Mitochondrion Connection: Common Ancestries, Common Mechanisms, Common Goals

    Lynn Margulis in the 1960s elegantly proposed a shared phylogenetic history between bacteria and mitochondria; this relationship has since become a cornerstone of modern cellular biology. Yet, an interesting facet of the interaction between the microbiome and mitochondria has been mostly ignored, that of the systems biology relationship that underpins host health and longevity.

    Alfredo Franco-Obregón, Jack A. Gilbert
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