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Klebsiella pneumoniae

  • Open Access
    Beneficial Chromosomal Integration of the Genes for CTX-M Extended-Spectrum β-Lactamase in <em>Klebsiella pneumoniae</em> for Stable Propagation
    Research Article | Clinical Science and Epidemiology
    Beneficial Chromosomal Integration of the Genes for CTX-M Extended-Spectrum β-Lactamase in Klebsiella pneumoniae for Stable Propagation

    Dominant F-type plasmids harboring the gene have been pointed out to be responsible for the dissemination of the CTX-M extended-spectrum-β-lactamase (ESBL)-producing K. pneumoniae. Recently, the emergence of K. pneumoniae isolates with the blaCTX-M gene in their chromosomes has...

    Eun-Jeong Yoon, Bareum Gwon, Changseung Liu, Dokyun Kim, Dongju Won, Sung Gyun Park, Jong Rak Choi, Seok Hoon Jeong
  • Open Access
    Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process
    Research Article | Molecular Biology and Physiology
    Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process

    Although they are often nonconjugative, large virulence plasmids are increasingly detected in clinical K. pneumoniae and contribute to the hypervirulence phenotype of this organism. In this study, we demonstrated that the virulence-encoding region that originated from virulence plasmid pLVPK actively interacted with different types of plasmids via homologous...

    Xuemei Yang, Lianwei Ye, Edward Wai-Chi Chan, Rong Zhang, Sheng Chen
  • Open Access
    Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria
    Research Article | Molecular Biology and Physiology
    Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria

    Gram-negative carbapenem-resistant bacteria are a major threat to global health. The use of genome-wide screening approaches to probe for genes or mutations enabling resistance can lead to identification of molecular markers for diagnostics applications. We describe an approach called Mut-Seq that couples chemical mutagenesis and next-generation sequencing for studying resistance to imipenem in the Gram-negative bacteria...

    Jessica Y. El Khoury, Alexandra Maure, Hélène Gingras, Philippe Leprohon, Marc Ouellette
  • Open Access
    Network Integrative Genomic and Transcriptomic Analysis of Carbapenem-Resistant <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> Strains Identifies Genes for Antibiotic Resistance and Virulence
    Research Article | Novel Systems Biology Techniques
    Network Integrative Genomic and Transcriptomic Analysis of Carbapenem-Resistant Klebsiella pneumoniae Strains Identifies Genes for Antibiotic Resistance and Virulence

    Klebsiella pneumoniae is a major bacterial pathogen that causes pneumonia and urinary tract infections in human. K. pneumoniae infections are treated with carbapenem, but carbapenem-resistant K. pneumoniae has been spreading...

    Muyoung Lee, Naina Adren Pinto, Chan Yeong Kim, Sunmo Yang, Roshan D’Souza, Dongeun Yong, Insuk Lee
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