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host response

  • Open Access
    Interactions between the Gut Microbiome and Mucosal Immunoglobulins A, M, and G in the Developing Infant Gut
    Editor's Pick Research Article | Host-Microbe Biology
    Interactions between the Gut Microbiome and Mucosal Immunoglobulins A, M, and G in the Developing Infant Gut

    Antibodies are secreted into the gut and attach to roughly half of the trillions of bacterial cells present. When babies are born, the breastmilk supplies these antibodies until the baby’s own immune system takes over this task after a few weeks. The vast majority of these antibodies are IgA, but two other types, IgG and IgM, are also present in the gut. Here, we ask if these three different antibody types target different types of...

    Anders Janzon, Julia K. Goodrich, Omry Koren, the TEDDY Study Group, Jillian L. Waters, Ruth E. Ley
  • Open Access
    Defining Microbiome Health through a Host Lens
    Special Issue Perspective | Host-Microbe Biology
    Defining Microbiome Health through a Host Lens

    We are walking ecosystems, inoculated at birth with a unique set of microbes that are integral to the functioning of our bodies. The physiology of our commensal microbiota is intertwined with our metabolism, immune function, and mental state.

    Sean M. Gibbons
  • Open Access
    Genetic and Transcriptional Analysis of Human Host Response to Healthy Gut Microbiota
    Editor's Pick Research Article | Novel Systems Biology Techniques
    Genetic and Transcriptional Analysis of Human Host Response to Healthy Gut Microbiota
    Allison L. Richards, Michael B. Burns, Adnan Alazizi, Luis B. Barreiro, Roger Pique-Regi, Ran Blekhman, Francesca Luca
  • Open Access
    A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease
    Research Article | Host-Microbe Biology
    A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease

    Making the most of “big data” is one of the core challenges of current biology. There is a large array of heterogeneous data sets of host gene responses to infection, but these data sets do not inform us about gene function and require specialized skill sets and training for their utilization. Here we describe an approach that combines and simplifies these data sets, distilling this information into a single list of genes commonly...

    Jacqueline U. McDonald, Myrsini Kaforou, Simon Clare, Christine Hale, Maria Ivanova, Derek Huntley, Marcus Dorner, Victoria J. Wright, Michael Levin, Federico Martinon-Torres, Jethro A. Herberg, John S. Tregoning
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