gut microbiome
Editor's Pick Research Article | Host-Microbe BiologyFunctional Changes in the Gut Microbiome Contribute to Transforming Growth Factor β-Deficient Colon CancerMost research on the gut microbiome in colon cancer focuses on taxonomic changes at the genus level using 16S rRNA gene sequencing. Here, we develop a new methodology to integrate DNA and RNA data sets to examine functional shifts at the species level that are important to tumor development. We uncover several metabolic pathways in the microbiome that, when perturbed by host genetics and H. hepaticus inoculation, contribute to...
Editor's Pick Research Article | Host-Microbe BiologyModerate Exercise Has Limited but Distinguishable Effects on the Mouse MicrobiomeThe bacteria that live in our gut have a complex yet vital relationship with our health. Environmental factors that influence the gut microbiome are of great interest, as recent research demonstrates that these microbes, mostly bacteria, are important for normal host physiology. Diseases such as obesity, diabetes, inflammatory bowel disease, and colon cancer have also been linked to shifts in the microbiome. Exercise is known to have...
Research Article | Host-Microbe BiologyFluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in MiceFluoride has been added to drinking water and dental products since the 1950s. The beneficial effects of fluoride on oral health are due to its ability to inhibit the growth of bacteria that cause dental caries. Despite widespread human consumption of fluoride, there have been only two studies of humans that considered the effect of fluoride on human-associated microbial communities, which are increasingly understood to play important...
Research Article | Host-Microbe BiologyMeta-analysis To Define a Core Microbiota in the Swine GutThe results of this meta-analysis demonstrate that “study” and GI sample location are the most significant factors in shaping the swine gut microbiota. However, in comparisons of results from different studies, some biological factors may be obscured by technical variation among studies. Nonetheless, there are some bacterial taxa that appear to form a core microbiota within the swine GI tract regardless of country of origin, diet, age,...