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group B Streptococcus

  • Open Access
    Multidimensional Proteome Profiling of Blood-Brain Barrier Perturbation by Group B <em>Streptococcus</em>
    Research Article | Host-Microbe Biology
    Multidimensional Proteome Profiling of Blood-Brain Barrier Perturbation by Group B Streptococcus

    Group B Streptococcus (GBS) meningitis remains a major cause of poor health outcomes very early in life. Both the host-pathogen relationship leading to disease and the massive host response to infection contributing to these poor outcomes are orchestrated at the tissue and cell type levels. GBS meningitis is thought to result when bacteria present in the blood circumvent the selectively permeable vascular barriers that feed the...

    Anaamika Campeau, Robert H. Mills, Marie Blanchette, Kaja Bajc, Mario Malfavon, Roeben N. Munji, Liwen Deng, Bryan Hancock, Kathryn A. Patras, Joshua Olson, Victor Nizet, Richard Daneman, Kelly Doran, David J. Gonzalez
  • Open Access
    Parallel Evolution of Group B <em>Streptococcus</em> Hypervirulent Clonal Complex 17 Unveils New Pathoadaptive Mutations
    Research Article | Ecological and Evolutionary Science
    Parallel Evolution of Group B Streptococcus Hypervirulent Clonal Complex 17 Unveils New Pathoadaptive Mutations

    The incidence of group B Streptococcus (GBS) neonatal disease continues to be a significant cause of concern worldwide. Strains belonging to clonal complex 17 (CC17) are the most frequently responsible for GBS infections in neonates, especially among late-onset disease cases. Therefore, we undertook the largest genomic study of GBS CC17 strains to date to decipher the genetic bases of their remarkable colonization and infection...

    Alexandre Almeida, Isabelle Rosinski-Chupin, Céline Plainvert, Pierre-Emmanuel Douarre, Maria J. Borrego, Claire Poyart, Philippe Glaser
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