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evolutionary biology

  • Open Access
    Experimental Evolution <em>In Vivo</em> To Identify Selective Pressures during Pneumococcal Colonization
    Editor's Pick Research Article | Host-Microbe Biology
    Experimental Evolution In Vivo To Identify Selective Pressures during Pneumococcal Colonization

    Evolution is a powerful force that can be experimentally harnessed to gain insight into how populations evolve in response to selective pressures. Herein we tested the applicability of experimental evolutionary approaches to gain insight into how the major human pathogen Streptococcus pneumoniae responds to repeated colonization events using a murine model. These...

    Vaughn S. Cooper, Erin Honsa, Hannah Rowe, Christopher Deitrick, Amy R. Iverson, Jonathan J. Whittall, Stephanie L. Neville, Christopher A. McDevitt, Colin Kietzman, Jason W. Rosch
  • Open Access
    Quantitative Models of Phage-Antibiotic Combination Therapy
    Research Article | Ecological and Evolutionary Science
    Quantitative Models of Phage-Antibiotic Combination Therapy

    This work develops and analyzes a novel model of phage-antibiotic combination therapy, specifically adapted to an in vivo context. The objective is to explore the underlying basis for clinical application of combination therapy utilizing bacteriophage that target antibiotic efflux pumps in Pseudomonas aeruginosa. In doing so, the paper addresses three key...

    Rogelio A. Rodriguez-Gonzalez, Chung Yin Leung, Benjamin K. Chan, Paul E. Turner, Joshua S. Weitz
  • Open Access
    Seven Billion Microcosms: Evolution within Human Microbiomes
    Special Issue Perspective | Ecological and Evolutionary Science
    Seven Billion Microcosms: Evolution within Human Microbiomes

    Rational microbiome-based therapies may one day treat a wide range of diseases and promote wellness. Yet, we are still limited in our abilities to employ such therapies and to predict which bacterial strains have the potential to stably colonize a person.

    Tami D. Lieberman
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