dysbiosis
Research Article | Host-Microbe BiologyConsumption of a Western-Style Diet Modulates the Response of the Murine Gut Microbiome to CiprofloxacinDue to the growing incidence of disorders related to antibiotic-induced dysbiosis, it is essential to determine how our “Western”-style diet impacts the response of the microbiome to antibiotics. While diet and antibiotics have profound impacts on gut microbiome composition, little work has been done to examine their combined effects. Previous work has shown that nutrient availability, influenced by diet, plays an important role in...
Research Article | Host-Microbe BiologyGut Microbiota Dysbiosis Is Associated with Altered Bile Acid Metabolism in Infantile CholestasisLiver health, fecal bile acid (BA) concentrations, and gut microbiota composition are closely connected. BAs and the microbiome influence each other in the gut, where bacteria modify the BA profile, while intestinal BAs regulate the growth of commensal bacteria, maintain the barrier integrity, and modulate the immune system. Previous studies have found that the co-occurrence of gut microbiota dysbiosis and BA metabolism alteration is...
Research Article | Host-Microbe BiologyThe Oral Mouse Microbiome Promotes Tumorigenesis in Oral Squamous Cell CarcinomaThere is growing evidence that changes in the microbiome are associated with carcinogenesis. To date, no consistent oral microbiome composition associated with OSCC has been identified. Longitudinal and functional studies like the study presented here should yield a better understanding of the role that the oral microbiome plays in OSCC. Our findings, obtained using a germ-free mouse model, indicate that the presence of different oral...
Research Article | Host-Microbe BiologyAltered Bacterial-Fungal Interkingdom Networks in the Guts of Ankylosing Spondylitis PatientsThe human gut is colonized by diverse fungi (mycobiota), and fungi have long been suspected in the pathogenesis of SpA. Our study unraveled a disease-specific interkingdom network alteration in AS, suggesting that fungi, or the interkingdom interactions between bacteria and fungi, may play an essential role in AS development. However, our study is limited by sample size, and in-depth mechanism studies and additional large-scale...