cofactor biosynthesis
Research Article | Molecular Biology and PhysiologyCellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in MycobacteriaMycobacteria are major environmental microorganisms and cause many significant diseases, including tuberculosis. Mycobacteria make an unusual vitamin-like compound, F420, and use it to both persist during stress and resist antibiotic treatment. Understanding how mycobacteria make F420 is important, as this process can be targeted to create new drugs to combat infections like tuberculosis. In this study, we show...