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biosynthetic gene clusters

  • Open Access
    Phylogenetic Distribution of Secondary Metabolites in the <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Species Complex
    Observation
    Phylogenetic Distribution of Secondary Metabolites in the Bacillus subtilis Species Complex

    Members of the B. subtilis species complex are commonly recognized producers of secondary metabolites, among those, the production of antifungals, which makes them promising biocontrol strains. While there are studies examining the distribution of well-known secondary metabolites in Bacilli, intraspecies clade-specific distribution has not been systematically...

    Kat Steinke, Omkar S. Mohite, Tilmann Weber, Ákos T. Kovács
  • Open Access
    Genomic and Chemical Diversity of <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Secondary Metabolites against Plant Pathogenic Fungi
    Research Article | Ecological and Evolutionary Science
    Genomic and Chemical Diversity of Bacillus subtilis Secondary Metabolites against Plant Pathogenic Fungi

    Secondary or specialized metabolites with antimicrobial activities define the biocontrol properties of microorganisms. Members of the Bacillus genus produce a plethora of secondary metabolites, of which nonribosomally produced lipopeptides in particular display strong antifungal activity.

    Heiko T. Kiesewalter, Carlos N. Lozano-Andrade, Mario Wibowo, Mikael L. Strube, Gergely Maróti, Dan Snyder, Tue Sparholt Jørgensen, Thomas O. Larsen, Vaughn S. Cooper, Tilmann Weber, Ákos T. Kovács
  • Open Access
    <em>MetaMed</em>: Linking Microbiota Functions with Medicine Therapeutics
    Opinion/Hypothesis | Therapeutics and Prevention
    MetaMed: Linking Microbiota Functions with Medicine Therapeutics

    Understanding how the human microbiome affects human health has consequences for treating disease and minimizing unwanted side effects in clinical research.

    Han Zhao, Shaliu Fu, Yifei Yu, Zhanbing Zhang, Ping Li, Qin Ma, Wei Jia, Kang Ning, Shen Qu, Qi Liu
  • Open Access
    Exploration of the Biosynthetic Potential of the <em>Populus</em> Microbiome
    Research Article | Host-Microbe Biology
    Exploration of the Biosynthetic Potential of the Populus Microbiome

    The plant root microbiome is one of the most diverse and abundant biological communities known. Plant-associated bacteria can have a profound effect on plant growth and development, and especially on protection from disease and environmental stress. These organisms are also known to be a rich source of antibiotic and antifungal drugs. In order to better understand the ways bacterial communities influence plant health, we evaluated the...

    Patricia M. Blair, Miriam L. Land, Marek J. Piatek, Daniel A. Jacobson, Tse-Yuan S. Lu, Mitchel J. Doktycz, Dale A. Pelletier
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