bile acids
Research Article | Host-Microbe BiologyGut Microbiota Dysbiosis Is Associated with Altered Bile Acid Metabolism in Infantile CholestasisLiver health, fecal bile acid (BA) concentrations, and gut microbiota composition are closely connected. BAs and the microbiome influence each other in the gut, where bacteria modify the BA profile, while intestinal BAs regulate the growth of commensal bacteria, maintain the barrier integrity, and modulate the immune system. Previous studies have found that the co-occurrence of gut microbiota dysbiosis and BA metabolism alteration is...
Special Issue Perspective | Therapeutics and PreventionBeyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized TherapeuticsOver the past 10 years, microbiome research has focused on defining the structures associated with different disease states in multiple systems, but has fallen short on showing causation. Prior omic studies have generated many new hypotheses, but moving forward we need to start dissecting the function of each bacterium alone and in concert with complex bacterial communities in well-characterized systems.