antivirulence
- Editor's Pick Research Article | Therapeutics and PreventionStable Neutralization of a Virulence Factor in Bacteria Using Temperate Phage in the Mammalian Gut
With the increasing frequency of antibiotic resistance, it is critical to explore new therapeutic strategies for treating bacterial infections. Here, we use a temperate phage, i.e., one that integrates itself into the bacterial genome, to neutralize the expression of a virulence factor by modifying bacterial function at the genetic level. We show that Shiga toxin production can be significantly reduced in vitro and in the...