TABLE 1

IMP MICs for E. coli ATCC 25922 mutants and amino acid substitutions detected in genes mutated in at least three mutants

TABLE 1
  • a Mutants are listed in ascending order of IMP MIC.

  • b MICs were monitored with at least three biological replicates. For all differences of 2-fold or higher, there was no variability in the observed MICs.

  • c Mutations correspond to amino acid substitutions, and numbers refer to amino acid positions in the protein. In the case of small insertions (Ins) or deletions (Del), the number indicated refers to the nucleotide position at which these occurred in the gene. Asterisks denote stop codons. ID, identifier. Mutations indicated in bold have been functionally tested for their role in IMP resistance by individual transformation in E. coli ATCC 25922 (see Table 5).