TABLE 2

Dimorphic transition-associated genes found in ΔbrlA and ΔabaA transcriptomes

Gene category
and namea
Tag locusbAnnotationΔbrlA/WTΔabaA/WT
log2RPadjustedlog2RPadjusted
Central developmental pathway
    brlABBA_07544C2H2 transcription factor BrlA−6.2150.0000
    abaABBA_00300Conidiation factor AbaA−1.9910.0000
    wetABBA_06126Conidial maturation factor WetA−0.7300.0065−0.7940.0008
    vosABBA_01023Velvet protein VosA−0.5000.0815−1.8510.0000
Putative dimorphic switch genes
    cdc42BBA_01874Cell division control protein 420.3150.3189−0.3340.1225
    drkABBA_01218Group III histidine kinase HK30.5680.0299−0.2440.2699
    pakABBA_07438PAK kinase−0.2470.4557−0.4420.0418
    pakBBBA_04136Protein kinase CHM10.1100.7880−0.3090.1519
    racABBA_08808Small GTPase, Rho type0.3420.24680.1330.5968
    ras1BBA_04387Ras GTPase 1 (Ras1)−0.2740.4143−0.2350.3013
    ras2BBA_04671Ras GTPase 2 (Ras2)−0.3110.5188−0.4410.0713
    ryp1BBA_06411Protein Ryp10.1420.9702−1.1260.0004
    ryp2BBA_05501Protein Ryp20.4620.10650.2260.3463
MAPK cascaded pathways
    ste11BBA_02280MAPK kinase kinase Ste110.8350.00110.8210.0040
    ste7BBA_04254MAPK kinase Ste7−0.3550.2180−0.5430.0077
    fus3BBA_01244MAPK Fus3−0.2500.4698−0.1010.6658
    ssk2BBA_00937MAPK kinase kinase Ssk20.0270.96200.0760.7790
    pbs2BBA_02330MAPK kinase Pbns20.0500.9158−0.0260.9326
    hog1BBA_05209MAPK Hog10.8140.02981.2070.0240
    bck1BBA_01318MAPK kinase kinase Bck1−0.0650.8808−0.3000.1701
    mkk1BBA_01095MAPK kinase Mkk1−0.1090.7935−0.1350.5861
    slt2BBA_03334MAPK Slt2−1.0790.0000−0.4810.0169
  • a Putative dimorphic switch genes are homologous to those of human mycopathogens listed in a review (18).

  • b Gene accession codes in B. bassiana genome under the NCBI accession no. NZ_ADAH00000000.