TABLE 1

Gene essentialities and in silico essentiality predictions of antitubercular drug target genesa

Gene (locus tag)Drug(s)Presence of core/soft core
gene (% of strains in
which it is conserved)
inhA (Rv1484)Isoniazid-ethionamideYes (96)
embA (Rv3794)EthambutolNo (79)
embB (Rv3795)EthambutolNo (83)
rpoB (Rv0667)RifampinYes (97)
atpE (Rv1305)BedaquilineYes (100)
gyrA (Rv0006)FluoroquinolonesYes (99)
gyrB (Rv0005)FluoroquinolonesNo (89)
dfrA (Rv2763c)para-Aminosalicylic acidYes (99)
alr (Rv3423c)d-CycloserineYes (98)
  • a Every listed gene was essential in MtbYM rich medium.