TABLE 2

Operons associated with production of citramalic acid by an E. coli cell factory that were differentially regulated ≥2-fold (adjusted P value of ≤0.05) relative to control fermentationsa

Gene or operonFunctionFold changeDirection of regulation
trpLEDCBATryptophan biosynthesis5.1Up
ygbJKHypothetical protein4.1Down
malK-lamB-malMMaltose transport3.8Up
exuTHexuronate transport3.6Down
cysDNCSulfur metabolism3.1Up
cysPUWAMSulfur metabolism2.8Up
fliAZ-tcyJFlagellar biosynthesis2.6Up
  • a Fold change is for the first gene in the operon unless indicated otherwise by boldface type.