TABLE 3

Differentially regulated sRNA molecules during citramalate production

sRNAFunctionFold change
Preinduction samplesaProduction strain vs control strainb
CS2CS3TS2TS3TS2:CS3TS3:CS3
ChiXChitosugar catabolism3.71.72.51.7NScNS
CsrBAntagonist of global translational regulator CsrA3.01.3NS0.30.40.2
GadYAcid tolerance—enhances stability of gadX transcriptNSNS1.32.12.03.0
MicFRegulation of OmpF2.31.6NSNSNSNS
RprAActivation of RpoS-dependent acid toleranceNSNS1.32.51.72.8
RybARegulation of TyrR2.41.3NSNSNSNS
RyeAPossible regulator of OmpD3.01.7NSNSNSNS
RyfDOverexpression inhibits biofilm formation2.41.3NSNSNSNS
RygDUnknown2.61.4NSNSNSNS
RygEUnknown2.61.4NSNSNSNS
RyhBIron homeostasis3.51.53.31.6NSNS
RyjAUpregulated in intracellular Salmonella3.12.02.22.1NSNS
SroCOverexpression inhibits biofilm formation0.40.5NSNSNSNS
SroGPhantom gene?2.71.4NSNSNSNS
TffProbable attenuator of rpsB expression2.21.4NSNSNSNS
  • a Differences in the abundances of the indicated sRNA species relative to the preinduction samples (CS1 and TS1). Only those sRNA species that exhibited ≥2-fold change (FDR adjusted P value of ≤0.05) for one or more samples are shown.

  • b Differences in the abundances of the indicated sRNA species in the production strain (TS2 and TS3) relative to those in the control strain (CS2 and CS3). Only those sRNA species that exhibited ≥2-fold change (unadjusted P value of ≤0.05) for one or more comparisons are shown.

  • c NS, not significant.