TABLE 2

Calculated key fluxes by constraint-based metabolic modeling

CharacteristicMetabolic flux (mmol ⋅ gDW−1 ⋅ h−1)FDR
ControlColistin (2 mg/liter)
Biomass formation (h−1)0.82 ± 0.000.57 ± 0.001.0 × 10−51
O2 uptake−45.3 ± 0.02−42.9 ± 2.445.1 × 10−20
CO2 emission48.1 ± 0.2246.3 ± 2.442.6 × 10−12
Respiratory quotient1.06 ± 0.001.08 ± 0.021.8 × 10−18
F0F1-ATPase73.60 ± 0.2178.2 ± 3.167.3 × 10−11
P/O ratio1.70 ± 0.011.87 ± 0.042.9 × 10−13
Nutrient uptake (mmol of carbon ⋅ gDW−1 ⋅ h−1)a−77.6 ± 0.12−64.0 ± 0.741.3 × 10−16
  • a Calculated by summing up the moles of carbon of each uptaking nutrient.