TABLEĀ 2

Key gut microbiota composition and metabolites responsible for distinguishing among children with ASD and children with typical development

Marker namesMarker typeDescriptionFDR value
(Deseq2)
Regulation
mode
d-Glutamine and d-glutamate metabolismGut microbiota pathwaysGlutamate metabolism5.5893E-05Down
2-Keto-glutaramic acidGut metabolitesGlutamate metabolism0.009440927Down
l-Aspartic acidGut metabolitesGlutamate metabolism0.015566567Down
Bacteroides vulgatusGut microbiota taxonsGlutamate-fermenting commensal0.005836312Down
Benzoate degradationGut microbiota pathwaysAromatic compound metabolism0.012717845Up
Naphthalene degradationGut microbiota pathwaysAromatic compound metabolism0.025979256Up
Tyrosine metabolismGut microbiota pathwaysAromatic compound metabolism0.011855325Up
BenzaldehydeGut metabolitesAromatic compound metabolism0.00746784Down
l-PhenylalanineGut metabolitesAromatic compound metabolism0.014748155Down
l-TyrosineGut metabolitesAromatic compound metabolism0.004732451Down
Chenodeoxycholic acid 3-sulfateGut metabolitesGut bile acid metabolism0.046136738Up
Taurocholic acidGut metabolitesGut bile acid metabolism0.028487916Up
EpinephrineGut metabolitesGut hormone0.019309289Down
11-Deoxy PGF2Gut metabolitesGut hormone1.36591E-10Down
CortisolGut metabolitesGut hormone1.99163E-07Down
Eggerthella lentaGut microbiota taxonsBile acid metabolism taxons0.013429179Up
Clostridium botulinum A3 strain Loch MareeGut microbiota taxonsBile acid metabolism taxons0.021268458Up
Clostridium botulinum Ba4 strain 657Gut microbiota taxonsBile acid metabolism taxons0.033169563Up
Eggerthella lenta DSM 2243Gut microbiota taxonsBile acid metabolism taxons0.010687164Up