TABLE 1

Summary of the gene-based comparisons of the CFA/I and CS6 genomes

Group 1aGroup 2No. of
genomes
in group 1
No. of
genomes
in group 2
No. of gene clustersb
All
genomes
≥50%
genomes
≥1
genome
CFA/ICS61428721931,771
CS6CFA/I8714241072,327
CFA/ICS6+ reference ETEC14212421231,379
CS6CFA/I+ reference ETEC871794421,227
Phylogroup A CFA/IPhylogroup B1 CFA/I119221004222,091
Phylogroup B1 CFA/IPhylogroup A CFA/I221191374781,142
CFA/I ETEC lineage L3Other CFA/I21121119243665
CFA/I ETEC lineage L6Other CFA/I105371462601,201
CFA/I ETEC lineage L15Other CFA/I14128157270420
Phylogroup A CS6Phylogroup B1 CS61671223611,407
Phylogroup B1 CS6Phylogroup A CS67116583072,246
CS6 ETEC lineage L4Other CS6978136166380
CS6 ETEC lineage L5Other CS6533450139982
CS6 ETEC lineage L8Other CS61671104267459
  • a The de novo LS-BSR analysis included 142 CFA/I genomes (ST+, LT, and CFA/I+), 87 CS6 genomes (ST+, LT, and CS6+), and 37 reference ETEC genomes (LT+ and/or ST+ but not containing CFA/I or CS6). There were 3,567 gene clusters identified with significant similarity (BSR of ≥0.9) in all 266 ETEC genomes analyzed (CS6, CFA/I, and reference ETEC).

  • b Data represent numbers of gene clusters that were present in all genomes, ≥50% of the genomes, or ≥1 of the genomes of group 1 (BSR of ≥0.9) and absent from all of the genomes of group 2 (BSR of <0.4).