TABLE 2

Antibiotic resistance gene products enriched by strain origin (P < 0.01 and FDR q <0.1) for B. cereus for origins with n ≥ 3a

B. cereus ARG productAntibiotic class
or other
% of strains from origin (n):FDR q
BE-ISS (8)Soil (11)Human (33)
Metallothiol transferase FosB 2Fosfomycin0.045.584.80.001
UDP-4-amino-4-deoxy-l-arabinose–oxoglutarate aminotransferasePolymyxin0.054.50.00.005
Multidrug resistance protein EbrBMultidrug100.027.357.60.045
Beta-lactamase 3Penicillin0.063.618.20.077
Cadmium resistance transcription regulatory protein CadCHeavy metal*0.09.124.20.077
Multidrug resistance protein StpMultidrug100.063.6100.00.080
  • a Percentage of strains from the respective origins encoding each function are listed. Gene products that were more frequently present in ISS strains than soil- and/or putatively commensal human-derived strains are displayed in bold. *, not an antibiotic class, though can be associated with antibiotic resistance.