TABLE 1

Differential expression of genes of interest after PCP exposurea

GeneProductlog2 Δ expression
(15 min)
FDRlog2 Δ expression
(5 h)
FDR
pcpRPCP transcriptional activator3.21*2.9e−1163.90*1.2e−173
pcpBPCP hydroxylase6.89*0.0e+08.91*0.0e+00
pcpDTCBQ reductase5.40*0.0e+07.04*0.0e+00
pcpCTCHQ dehalogenase0.171.4e−011.74*5.8e−65
pcpADCHQ dioxygenase5.65*1.8e−807.32*1.1e−124
pcpEMaleylacetate reductase4.47*2.9e−2425.96*0.0e+00
pcaJ3-Oxoacid CoA transferase, B subunit0.341.3e−031.02*7.9e−26
pcaI3-Oxoacid CoA transferase, A subunit−0.133.5e−011.01*2.2e−17
pcaFBeta-ketoadipyl CoA thiolase0.056.6e−010.907.4e−16
gshAGlutamate-cysteine ligase2.83*1.5e−1801.24*2.3e−35
gshBGlutathione synthetase1.56*6.2e−530.421.9e−04
emrRTetR family transcriptional regulator5.16*5.3e−3083.88*1.9e−140
emrAEfflux pump membrane protein4.73*4.0e−2923.29*3.2e−107
emrBDrug resistance transporter4.63*0.0e+03.27*1.2e−207
fad1Fatty acid desaturase2.31*1.4e−1090.506.8e−06
fadD1Long-chain fatty acid-CoA ligase1.19*9.2e−24−0.097.1e−01
fadD2Long-chain fatty acid-CoA ligase2.81*3.1e−1081.73*3.9e−29
fadD3Long-chain fatty acid-CoA ligase4.82*5.3e−2701.38*1.8e−17
fadJ3-Hydroxybutyryl-CoA epimerase1.67*7.4e−750.613.1e−10
fadH12,4-Dienoyl-CoA reductase2.72*3.5e−620.594.2e−02
mdoGPeriplasmic glucan biosynthesis protein2.34*5.3e−840.504.6e−04
dgkADiacylglycerol kinase2.58*3.9e−1130.541.5e−04
  • a All differentially expressed genes are listed in Data Set S1A in the supplemental material. This table contains genes that are discussed in the text. Genes whose expression changes significantly after PCP exposure, determined by a fold change of >2 and a false-discovery rate (FDR) of <0.01. Asterisks indicate significant differences.