TABLE 3

Probiotic and placebo effects on absolutely quantified colonic fermentation metabolites after 4 weeks of intake

MetaboliteChemical
classa
Metabolite concentration withb:P value for
probiotic vs
placebo
ProbioticPlacebo
StartEndStartEnd
Acetate (mM)SCFA162.14 ± 75.53176.14 ± 81.55181.68 ± 80.74192.28 ± 85.310.869
Propionate (mM)SCFA42.49 ± 27.5338.86 ± 17.2140.33 ± 21.2941.20 ± 17.850.436
Butyrate (mM)SCFA28.31 ± 15.2929.90 ± 15.4230.12 ± 15.8534.09 ± 19.130.613
Isobutyrate (mM)BCFA3.15 ± 1.293.57 ± 1.713.15 ± 1.353.46 ± 1.570.815
Isovalerate (mM)BCFA1.94 ± 0.792.37 ± 1.192.07 ± 0.962.26 ± 1.200.457
Dimethyl
sulfide (µM)
S-compound0.01 (0.01–0.01)0.01 (0.01–0.01)0.01 (0.01–0.01)0.01 (0.01–0.01)0.855
p-Cresol (mM)Phenol0.61 ± 0.390.73 ± 0.490.68 ± 0.560.69 ± 0.580.498
Indole (µM)Indole2.79E−3 (1.20E−4
to 8.76E−3)
1.93E−3 (0 to
8.02E−3)
1.98E−3 (9.32E−4
to 4.61E−3)
3.09E−3 (1.38E−3
to 6.43E−3)
0.81
  • a SCFA, short-chain fatty acid; BCFA, branched-chain fatty acid.

  • b Except as noted, values are expressed as mean ± SD and were compared with paired two-sample t tests when the normality assumption was met. If not, data are represented as median with IQR in parentheses and were compared with Wilcoxon signed-rank tests.