TABLE 1

Characteristics of five stress response TFs

TFMr (Da)FamilyRegulatory function(s)EffectoraNo. of targetsbTarget TFs (total)
ArcA27,292OmpRAnoxic redox controlAcP89∼102AbgT, ArgR, BetI, FeaR, GadE, GadX,
GlcC, HcaR, LrhR, PdhR, RutR, UxpC,
YdcI (13)
McbR25,151GntRBiofilm formation
(colonic acid production)
None27∼36CaiF, GadX, YbdO, YbeF (4)
AI-226∼37
RcdA20,307TetRBiofilm formation
(csgD regulation)
Acetate (pH 6)31∼44AdiA, AppY, CsgD, RcdA, StpA, Sxy,
YgE (7)
SdiA28,117LuxRCell division and biofilm
formation
None48∼70AbgR, DpiB, DsdC, LeuO, PdhR, SlyA,
YdeF (7)
HSL-A77∼111
HSL-F67∼97
HSL-K57∼78
SlyA16,353MarRBiofilm formation
(hemolysin synthesis)
ppGpp10∼12FlhD, GadX, IclR, LeuO, MurR, SdiA,
SlyY, TreR, YlfB, YiiE (10)
  • a AI-1 (autoinducer 1) is represented by homoserine lactone (HSL) and HSL homologs (13). AI-2 (autoinducer 2) represents furanosyl borate diester. ppGpp (stringent response alarmone) represents guanosine tetraphosphate.

  • b The numbers of regulatory targets were determined by genomic SELEX screening (for details, see Fig. 8 and Table S3).