TABLE 3 

Genes present in significantly different frequencies between case and control patientsa

Reference genome
gene locus tag
AnnotationbFrequency, no. (%)P value
Casec (n = 38)Controld (n = 76)
KPK_RS16860, VK055_1478, KP1_RS09340Iron ABC transporter permease4 (10.5)29 (38.1)0.004369
KP1_RS12850, KPNJ1_RS13400, KPN_01704DeoR family protein/alkaline phosphatase32 (84.2)43 (56.6)0.005060
KPK_RS16855, VK055_1477, KP1_RS09345Amino acid ABC transporter substrate-binding protein4 (10.5)28 (36.8)0.005286
KPK_RS16810, VK055_1467, KP1_RS09395ePTS fructose transporter subunit IIA5 (13.1)30 (39.4)0.006209
KPK_RS16815, VK055_1468, KP1_RS09390PTS fructose transporter subunit IIC5 (13.1)30 (39.4)0.006209
KPK_RS16825, VK055_1470, KP1_RS09380Formate acetyltransferase5 (13.1)30 (39.4)0.006209
KPK_RS16830, VK055_1471, KP1_RS09375Pyruvate formate lyase II Activase5 (13.1)30 (39.4)0.006209
KPK_RS16840, VK055_1473, KP1_RS09365Phytanoyl-CoA dioxygenase5 (13.1)30 (39.4)0.006209
KPK_RS16845, VK055_1476, KP1_RS09360AraC family transcriptional regulator5 (13.1)30 (39.4)0.006209
KPK_RS16850, VK055_1475, KP1_RS09355Membrane protein5 (13.1)30 (39.4)0.006209
KPN_01782Deoxygluconate dehydrogenase26 (68.4)30 (39.4)0.007139
KPK_RS16865, VK055_1479, KP1_RS09335Iron ABC transporter substrate-binding protein5 (13.1)30 (39.4)0.007219
KPK_RS16820, VK055_1469, KP1_RS09385fPTS fructose transporter subunit IIB6 (15.8)32 (42.1)0.008326
KPK_RS16835, VK055_1472, KP1_RS09370PTS fructose transporter subunit IIB6 (15.8)32 (42.1)0.008326
KP1_RS12840, KPNJ1_RS13410, KPN_01702gDeoxyribose-phosphate aldolase31 (81.5)43 (56.6)0.009493
KP1_RS12835, KPNJ1_RS13415, KPN_01701Alkaline phosphatase/deoR31 (81.5)43 (56.6)0.009493
KP1_RS12830 KPNJ1_RS13420, KPN_01700Allulose-6-phosphate 3-epimerase31 (81.5)43 (56.6)0.009493
KP1_RS12825, KPNJ1_RS13425, KPN_01699Carbohydrate kinase (ribokinase)31 (81.5)43 (56.6)0.009493
KP1_RS12820, KPNJ1_RS13430, KPN_01698Permease31 (81.5)43 (56.6)0.009493
KP1_RS26720, KPK_RS27195hTellurium resistance protein TerF10 (26.3)6 (7.9)0.012875
KP1_RS26700, KPK_RS27215Tellurium resistance protein TerB10 (26.3)6 (7.9)0.012875
KP1_RS26655, KPK_RS27260Tellurium resistance protein TerW10 (26.3)6 (7.9)0.012875
KP1_RS26650, KPK_RS27270Tellurium resistance protein TerY10 (26.3)6 (7.9)0.012875
KPNJ1_01715Hypothetical protein13 (34.2)10 (13.2)0.013956
  • a Genes in operons were collapsed into one representative gene. Representative potential protective factors are shown in italic type, and potential risk factors are shown in italic boldface type.

  • b PTS, phosphotransferase system; CoA, coenzyme A.

  • c Patients with bloodstream infection or pneumonia.

  • d Patients with asymptomatic rectal colonization.

  • e Representative gene for KPK_RS16810, -16815, -16825, -16830, -16840, -16845, and -16850.

  • f Representative gene for KPK_RS16820 and -16835.

  • g Representative gene for KP1_RS12820 to -12840.

  • h Representative gene for KP1_RS26720, -26700, -26655, and -26650.