TABLE 2

List of primary interaction partners (HHEV) of HEV proteinsa

Viral proteinNo. of host
interaction
partners
Host proteins (gene symbol)
Primary interaction partners
of g-1 HEV
    Met19APCS, ACTG1, ACY1, ALDH1L1, ALDOB, AOX1, CES1, CTSF, DBF4B, FNDC1, GPRC5C, HEMK1,
KLHDC2, MAP2K5, PPIE, PSMB4, RBP4, SLC27A5, TUBB2A
    Y4DNAJA3, MAP1S, TIMM50, TPST2
    PCP5EEF1A1, EIF2AK4, PCDH8, RNF168, SLC22A12b
    V9ALB, BIRC6, BTBD6, C3, EIF4A2, FUS, MT-CO1, MT-ND1, UBBb
    X11AZGP1, RBP4, MT-ND4L, SLC35A2, GNB2L1, ALDOB, PSMB1, DAZAP2, C1orf61, DNAJB5, KREMEN1
    Hel9A2M, ACY1, ALDH1L1, C4A, GNB2, GOLGB1, HEMK1, TF, TM4SF4b
    RdRp41ACTG1, ADH1B, ALB, ALDOB, ALS2CL, APLP1, ATP9B, BTBD6, C3, C8A, CIRBP, COG1, DCXR EEF1A1,
EIF3A,b EIF4A2, FBOX31, FEZ1, GBE1,b H2AFY2, HN1, HP, LSAMP, MACF1, MAP1B, MARCKSL1,
MT-CO1, NEIL1, NR2F6, PCDL, PEBP1, PSAP, RNF187, RTN1, SARAF, SLC2A1, TF, TMX2, TUBB,
VTN, ZDHHC6
    ORF22PCBP1, RPL29
    ORF311BRD2, C1orf61, DBF4B, ITM2C, MAD2L1, MCOLN1, NRXN2, SDK2, TSG101, TSPAN7, U2SURP
    ORF426ALDOB, APOH, ASGR2, AZGP1, AZIN1, CLPP, CP, CSAD, CTSD, EEF1A1, EIF3A, EPS8, FAM35A, FGA,
FGB, GRB2, HNRNPLL, HP, HRG, KIAA1191, MPP1, MT-ATP6, MT-CO2, NPLOC4, SERPING1,
SLC26A10, TEKT4, TUBB
Primary interaction partners
of g-3 HEV
    Met11ACTG1, ACY1, ALDH1L1, AOX1, CES1, FNDC1, HEMK1, MAP2K5, PSMB4, RBP4, TUBB2A
    Y1MAP1S
    PCP2EEF1A1, SLC22A12
    V9ALB, BIRC6, BTBD6, C3, EIF4A2, FUS, MT-CO1, MT-ND1, UBB
    X10ALDOB, AZGP1, DAZAP2, DNAJB5, GNB2L1, KREMEN1, MT-ND4L, PSMB1, RBP4, SLC35A2
    Hel9A2M, ACY1, ALDH1L1, C4A, GNB2, GOLGB1, HEMK1, TF, TM4SF4
    RdRp23ACTG1, ALB, ALS2CL, BTBD6, C3, DCXR, EEF1A1, EIF3A, EIF4A2, FBXO31, FEZ1, GBE1, H2AFY2,
HN1, MACF1, MAP1B, PSAP, RNF187, SARAF, SLC2A1, TUBB, VTN, ZDHHC6
    ORF22PCBP1, RPL29
    ORF311BRD2, C1orf61, DBF4B, ITM2C, MAD2L1, MCOLN1, NRXN2, SDK2, TSG101, TSPAN7, U2SURP
Primary interaction partners of
g-1 HEV ORF1 polypeptide
    ORF1AY1, A2M, ACTG1, ACY1, ADH1B, ALDH1L1, ALDOB, ALS2CL, AOX1, APCS, APLP1, ATP9B, AZGP1,
BIRC6, BTBD6, C1orf61, C3, C4A, C8A, CES1, CIRBP, COG1, CTSF, DAZAP2, DBF4B, DCXR, DNAJB5,
EEF1A1, EIF2AK4, EIF4A2, FBOX31, FEZ1 FNDC1, FUS, GNB2, GNB2L1, GOLGB1, GPRC5C, H2AFY2,
HEMK1, HN1, HP, KLHDC2, KREMEN1, LSAMP, MACF1, MAP1B, MAP1S, MAP2K5, MARCKSL1,
MT-CO1, MT-ND1, MT-ND4L, NEIL1, NR2F6, PCDH8, PCDL, PEBP1, PPIE, PSAP, PSMB1, PSMB4,
RBP4, RNF168, RNF187, RTN1, SARAF, 27A5, SLC2A1, SLC35A2, TF, TIMM50, TMX2, TPST2, TUBB,
TUBB2A, VTN, ZDHHC6
  • a Names of proteins involved in interactions verified by coimmunoprecipitation assay are underlined.

  • b Host proteins that are unable to interact with the ORF1 polypeptide of g-1 HEV.