TABLE 3

Canonical pathwaysa

Ingenuity canonical pathwayMolecules
IFN signalingOAS1, IFIT1, IFN-γ, IFITM1, STAT1, IFN-A1/IFN-A13, IFIT3, STAT2, MX1, IFI35, IFITM3, PSMB8
Activation of IRF by cytosolic pattern recognition receptorsJun, DHX58, STAT2, IFIT2, IL-6, NFKBIA, IRF7, STAT1, TNF, IFN-A1/IFN-A13, ISG15, IFIH1, IL-10
Communication between innate and adaptive immune cellsIL-15, TNFSF13B, IFN-γ, CCL5, CXCL10, HLA-G, IL-6, CXCL8, IL-1RN, TNF, IFN-A1/IFN-A13, IL-10, HLA-B, CCL4
Role of hypercytokinemia/hyperchemokinemia in pathogenesis of influenzaIL-15, IL-1RN, IFN-γ, CCL5, CXCL10, TNF, IFN-A1/IFN-A13, CCL2, CCL4, IL-6, CXCL8
Role of pattern recognition receptors in recognition of bacteria and virusesEIF2AK2, OAS1, IFN-γ, C3, MYD88, CCL5, OAS2, IL-6, CXCL8, IRF7, TNF, IFN-A1/IFN-A13, OAS3, IFIH1, IL-10
Granulocyte adhesion and diapedesisCXCL9, CCL8, CCL7, CCL5, MMP9, CXCL10, CXCL2, CXCL8, CXCL11, IL-1RN, TNF, CCL2, MMP8, CCL4
Agranulocyte adhesion and diapedesisCXCL9, CCL8, CCL7, CCL5, MMP9, CXCL10, CXCL2, CXCL8, CXCL11, IL-1RN, TNF, CCL2, MMP8, CCL4
Role of cytokines in mediating communication between immune cellsIL-15, IL-1RN, IFN-γ, TNF, IFN-A1/IFN-A13, IL-20, IL-10, IL-6, CXCL8
Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17FIFN-γ, CCL5, TNF, CCL2, IL-10, CCL4, LCN2
Dendritic cell maturationFCGR1B, IL-15, MYD88, FCGR1A, STAT2, IL-6, NFKBIA, IL-1RN, STAT1, TNF, IFN-A1/IFN-A13, IL-10, HLA-B
  • a Ingenuity pathway analysis was applied to the top-scoring genes.