TABLE 1

Genes most frequently upregulated following RSV infectiona

Weighted scoreGene(s)
24 IFI27
23 IFIT3
18 GBP1
16 IFI44L
15 OAS3, IFI44, CXCL10
14 HP
12 ADAM33, OAS2, IL-1RN, IFIT2, HERC5, RSAD2/Viperin, ARG1, ISG15
11 CXCL11, STAT2, TNF, FCER1A, IRF7, FCGR1A, CA1, STAT1
10 IFN-γ, IFIT1, CCL5, EPSTI1, MX2
9 CEACAM6, C3, CCL8, CXCL9, TRAC, IFI35, MX1, MPO, LCN2, OTOF
8 VDR, BPGM, IFI6, IL-10, ANXA3, OLFM4, SAMHD1, SERPING1, DEFA1, IFN-A13, RTP4, NOS2A, AIM2, Jun, OASL, GBP4
7 SCGB1A1, ISG20, CHI3L1, OAS1A, MUC5AC, PRIC285, IL-6
6 IFITM3, IL-20, MMP8, DEFA4, OASL2, ATF3, CXCL2, TMC5, TF, HBBP1, FCGR1B, IFIH1, CXCL8, CCL4, IL-15, PRF1, ALAS2, NFKBIA, MSP, ELA2, KLRD1, IL-7, MMP9, CD14
5 DEFA3, THOC4, CEACAM8, IFIT5, LAMP3, ERAF, IFN-α, ALDH1A1, LGALS9, GZMB, LTF, CCL7, HBM, OAS1, CTNNAL1, WARS, LY6E, HBD, IGTP, S100A12, PSMB8, DHX58, IFI1, IFI47, CCL2, PSMB9, GNLY
4 EIF2AK2, MYD88, BATF2, CMPK2, GMPR, LILRB4, OSMR, IIGP1 TNFSF13B, DAXX, HLA-G, HSPA8, IL-18BP, NMI, HLA-B, SAMD9L, CD177, IIGP2, LAP3, GBP2, USP18, PLAC8, MS4A6D, FCGR1, IFITM1, PARP9, AIF1, SERPINA3G, IFI202B
  • a Genes were collated from multiple studies of RSV. A cutoff of a 2-fold increase in expression, compared to the reference group in the study from which the data were collated, was used when available. Genes were weighted as follows on the basis of the studies from which they were collated: human genetic studies, 4; human in vivo microarray studies, 3; human in vitro microarray studies, 2; mouse studies, 1. After weighting, genes were analyzed for multiple hits by a custom Perl script.