TABLE 1

Genes most frequently upregulated following RSV infectiona

Weighted scoreGene(s)
24IFI27
23IFIT3
18GBP1
16IFI44L
15OAS3, IFI44, CXCL10
14HP
12ADAM33, OAS2, IL-1RN, IFIT2, HERC5, RSAD2/Viperin, ARG1, ISG15
11CXCL11, STAT2, TNF, FCER1A, IRF7, FCGR1A, CA1, STAT1
10IFN-γ, IFIT1, CCL5, EPSTI1, MX2
9CEACAM6, C3, CCL8, CXCL9, TRAC, IFI35, MX1, MPO, LCN2, OTOF
8VDR, BPGM, IFI6, IL-10, ANXA3, OLFM4, SAMHD1, SERPING1, DEFA1, IFN-A13, RTP4, NOS2A, AIM2, Jun, OASL, GBP4
7SCGB1A1, ISG20, CHI3L1, OAS1A, MUC5AC, PRIC285, IL-6
6IFITM3, IL-20, MMP8, DEFA4, OASL2, ATF3, CXCL2, TMC5, TF, HBBP1, FCGR1B, IFIH1, CXCL8, CCL4, IL-15, PRF1, ALAS2, NFKBIA, MSP, ELA2, KLRD1, IL-7, MMP9, CD14
5DEFA3, THOC4, CEACAM8, IFIT5, LAMP3, ERAF, IFN-α, ALDH1A1, LGALS9, GZMB, LTF, CCL7, HBM, OAS1, CTNNAL1, WARS, LY6E, HBD, IGTP, S100A12, PSMB8, DHX58, IFI1, IFI47, CCL2, PSMB9, GNLY
4EIF2AK2, MYD88, BATF2, CMPK2, GMPR, LILRB4, OSMR, IIGP1 TNFSF13B, DAXX, HLA-G, HSPA8, IL-18BP, NMI, HLA-B, SAMD9L, CD177, IIGP2, LAP3, GBP2, USP18, PLAC8, MS4A6D, FCGR1, IFITM1, PARP9, AIF1, SERPINA3G, IFI202B
  • a Genes were collated from multiple studies of RSV. A cutoff of a 2-fold increase in expression, compared to the reference group in the study from which the data were collated, was used when available. Genes were weighted as follows on the basis of the studies from which they were collated: human genetic studies, 4; human in vivo microarray studies, 3; human in vitro microarray studies, 2; mouse studies, 1. After weighting, genes were analyzed for multiple hits by a custom Perl script.