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Research Article | Host-Microbe Biology

Microbe-Metabolite Associations Linked to the Rebounding Murine Gut Microbiome Postcolonization with Vancomycin-Resistant Enterococcus faecium

Andre Mu, Glen P. Carter, Lucy Li, Nicole S. Isles, Alison F. Vrbanac, James T. Morton, Alan K. Jarmusch, David P. De Souza, Vinod K. Narayana, Komal Kanojia, Brunda Nijagal, Malcolm J. McConville, Rob Knight, Benjamin P. Howden, Timothy P. Stinear
Manuel Liebeke, Editor
Andre Mu
aDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
bDoherty Applied Microbial Genomics, Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
cMicrobiological Diagnostic Unit Public Health Laboratory, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
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  • ORCID record for Andre Mu
Glen P. Carter
aDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
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Lucy Li
aDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
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Nicole S. Isles
aDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
cMicrobiological Diagnostic Unit Public Health Laboratory, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
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Alison F. Vrbanac
dDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA
eDepartment of Computer Science & Engineering, University of California San Diego, La Jolla, California, USA
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James T. Morton
fFlatiron Institute, Centre for Computational Biology, New York, New York, USA
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Alan K. Jarmusch
gSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, USA
hCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA
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  • ORCID record for Alan K. Jarmusch
David P. De Souza
iMetabolomics Australia, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Australia
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Vinod K. Narayana
iMetabolomics Australia, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Australia
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Komal Kanojia
jCentre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
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Brunda Nijagal
kDepartment of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia
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Malcolm J. McConville
iMetabolomics Australia, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Australia
kDepartment of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia
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Rob Knight
dDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA
eDepartment of Computer Science & Engineering, University of California San Diego, La Jolla, California, USA
lDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA
mCenter for Microbiome Innovation, University of California San Diego, La Jolla, California, USA
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Benjamin P. Howden
aDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
bDoherty Applied Microbial Genomics, Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
cMicrobiological Diagnostic Unit Public Health Laboratory, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
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Timothy P. Stinear
aDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
bDoherty Applied Microbial Genomics, Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
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Manuel Liebeke
Max Planck Institute for Marine Microbiology
Roles: Editor
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DOI: 10.1128/mSystems.00452-20
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Article Information

DOI 
https://doi.org/10.1128/mSystems.00452-20
PubMed 
32817384

Published By 
American Society for Microbiology Journals
History 
  • Received May 20, 2020
  • Accepted July 27, 2020
  • Published online August 18, 2020.

Copyright & Usage 
Copyright © 2020 Mu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Manuel Liebeke, Editor, Max Planck Institute for Marine Microbiology

Author Information

  1. Andre Mua,b,c,
  2. Glen P. Cartera,
  3. Lucy Lia,
  4. Nicole S. Islesa,c,
  5. Alison F. Vrbanacd,e,
  6. James T. Mortonf,
  7. Alan K. Jarmuschg,h,
  8. David P. De Souzai,
  9. Vinod K. Narayanai,
  10. Komal Kanojiaj,
  11. Brunda Nijagalk,
  12. Malcolm J. McConvillei,k,
  13. Rob Knightd,e,l,m,
  14. Benjamin P. Howdena,b,c and
  15. Timothy P. Stineara,b
  1. aDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
  2. bDoherty Applied Microbial Genomics, Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
  3. cMicrobiological Diagnostic Unit Public Health Laboratory, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
  4. dDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA
  5. eDepartment of Computer Science & Engineering, University of California San Diego, La Jolla, California, USA
  6. fFlatiron Institute, Centre for Computational Biology, New York, New York, USA
  7. gSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, USA
  8. hCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA
  9. iMetabolomics Australia, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Australia
  10. jCentre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
  11. kDepartment of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia
  12. lDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA
  13. mCenter for Microbiome Innovation, University of California San Diego, La Jolla, California, USA
  • Address correspondence to Andre Mu, andre.mu{at}unimelb.edu.au.
  • Benjamin P. Howden and Timothy P. Stinear contributed equally to this work.

  • Citation Mu A, Carter GP, Li L, Isles NS, Vrbanac AF, Morton JT, Jarmusch AK, De Souza DP, Narayana VK, Kanojia K, Nijagal B, McConville MJ, Knight R, Howden BP, Stinear TP. 2020. Microbe-metabolite associations linked to the rebounding murine gut microbiome postcolonization with vancomycin-resistant Enterococcus faecium. mSystems 5:e00452-20. https://doi.org/10.1128/mSystems.00452-20.

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Microbe-Metabolite Associations Linked to the Rebounding Murine Gut Microbiome Postcolonization with Vancomycin-Resistant Enterococcus faecium
Andre Mu, Glen P. Carter, Lucy Li, Nicole S. Isles, Alison F. Vrbanac, James T. Morton, Alan K. Jarmusch, David P. De Souza, Vinod K. Narayana, Komal Kanojia, Brunda Nijagal, Malcolm J. McConville, Rob Knight, Benjamin P. Howden, Timothy P. Stinear
mSystems Aug 2020, 5 (4) e00452-20; DOI: 10.1128/mSystems.00452-20

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Microbe-Metabolite Associations Linked to the Rebounding Murine Gut Microbiome Postcolonization with Vancomycin-Resistant Enterococcus faecium
Andre Mu, Glen P. Carter, Lucy Li, Nicole S. Isles, Alison F. Vrbanac, James T. Morton, Alan K. Jarmusch, David P. De Souza, Vinod K. Narayana, Komal Kanojia, Brunda Nijagal, Malcolm J. McConville, Rob Knight, Benjamin P. Howden, Timothy P. Stinear
mSystems Aug 2020, 5 (4) e00452-20; DOI: 10.1128/mSystems.00452-20
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KEYWORDS

microbiome
multiomics
metagenomics
metabolomics
gut microbiome
vancomycin-resistant enterococci
colonization
antimicrobial resistance
ceftriaxone

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