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Opinion/Hypothesis | Novel Systems Biology Techniques

Repurposing Didanosine as a Potential Treatment for COVID-19 Using Single-Cell RNA Sequencing Data

Fadhl M. Alakwaa
Jack A. Gilbert, Editor
Fadhl M. Alakwaa
aDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA
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  • ORCID record for Fadhl M. Alakwaa
Jack A. Gilbert
University of California San Diego
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DOI: 10.1128/mSystems.00297-20
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ABSTRACT

As of today (7 April 2020), more than 81,000 people around the world have died from the coronavirus disease 19 (COVID-19) pandemic. There is no approved drug or vaccine for COVID-19, although more than 10 clinical trials have been launched to test potential drugs. In an urgent response to this pandemic, I developed a bioinformatics pipeline to identify compounds and drug candidates to potentially treat COVID-19. This pipeline is based on publicly available single-cell RNA sequencing (scRNA-seq) data and the drug perturbation database “Library of Integrated Network-Based Cellular Signatures” (LINCS). I developed a ranking score system that prioritizes these drugs or small molecules. The four drugs with the highest total score are didanosine, benzyl-quinazolin-4-yl-amine, camptothecin, and RO-90-7501. In conclusion, I have demonstrated the utility of bioinformatics for identifying drugs than can be repurposed for potentially treating COVID-19 patients.

  • Copyright © 2020 Alakwaa.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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Repurposing Didanosine as a Potential Treatment for COVID-19 Using Single-Cell RNA Sequencing Data
Fadhl M. Alakwaa
mSystems Apr 2020, 5 (2) e00297-20; DOI: 10.1128/mSystems.00297-20

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Repurposing Didanosine as a Potential Treatment for COVID-19 Using Single-Cell RNA Sequencing Data
Fadhl M. Alakwaa
mSystems Apr 2020, 5 (2) e00297-20; DOI: 10.1128/mSystems.00297-20
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KEYWORDS

COVID-19
drug
repurposing

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