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Special Issue Perspective | Applied and Environmental Science

Culturing the Uncultured: Risk versus Reward

J. Cameron Thrash
J. Cameron Thrash
aDepartment of Biological Sciences, University of Southern California, Los Angeles, California, USA
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DOI: 10.1128/mSystems.00130-19
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    FIG 1

    Isolate 16S rRNA gene sequences deposited into GenBank by year. Nonlinear regression is shown in blue, with 95% confidence intervals shaded. (Inset) Cumulative isolate 16S rRNA gene sequences in GenBank over time. The code for Entrez searches and figure generation is available at https://github.com/jcthrash/16S_deposition.

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    FIG 2

    Possible EV outcomes for a hypothetical cultivation project with nine (i · cP) categories. The ratio of low-value to high-value isolates is plotted against the total number of isolates generated by any given combination of isolates in each category. Positive (pos) or negative (neg) expectation is orange or blue, respectively. Code for this simulation, including all isolate categories and number combinations, is available at https://github.com/jcthrash/ev_sim_100K.

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Culturing the Uncultured: Risk versus Reward
J. Cameron Thrash
mSystems May 2019, 4 (3) e00130-19; DOI: 10.1128/mSystems.00130-19

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Culturing the Uncultured: Risk versus Reward
J. Cameron Thrash
mSystems May 2019, 4 (3) e00130-19; DOI: 10.1128/mSystems.00130-19
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KEYWORDS

cost-benefit analysis
cultivation
environmental microbiology

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