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Research Article | Therapeutics and Prevention

Combinatorial Approaches to Viral Attenuation

Matthew L. Paff, Benjamin R. Jack, Bartram L. Smith, James J. Bull, Claus O. Wilke
Olga Zhaxybayeva, Editor
Matthew L. Paff
aDepartment of Integrative Biology, The University of Texas at Austin, Austin, Texas, USA
bInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Benjamin R. Jack
aDepartment of Integrative Biology, The University of Texas at Austin, Austin, Texas, USA
bInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Bartram L. Smith
aDepartment of Integrative Biology, The University of Texas at Austin, Austin, Texas, USA
bInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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James J. Bull
aDepartment of Integrative Biology, The University of Texas at Austin, Austin, Texas, USA
bInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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Claus O. Wilke
aDepartment of Integrative Biology, The University of Texas at Austin, Austin, Texas, USA
bInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
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  • ORCID record for Claus O. Wilke
Olga Zhaxybayeva
Dartmouth College
Roles: Editor
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DOI: 10.1128/mSystems.00046-18
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Article Information

DOI 
https://doi.org/10.1128/mSystems.00046-18

Published By 
American Society for Microbiology Journals
History 
  • Received April 2, 2018
  • Accepted July 5, 2018
  • Published online July 31, 2018.

Copyright & Usage 
Copyright © 2018 Paff et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Olga Zhaxybayeva, Editor, Dartmouth College

Author Information

  1. Matthew L. Paffa,b,
  2. Benjamin R. Jacka,b,
  3. Bartram L. Smitha,b,
  4. James J. Bulla,b and
  5. Claus O. Wilkea,b
  1. aDepartment of Integrative Biology, The University of Texas at Austin, Austin, Texas, USA
  2. bInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA
  • Address correspondence to Claus O. Wilke, wilke{at}austin.utexas.edu.
  • Citation Paff ML, Jack BR, Smith BL, Bull JJ, Wilke CO. 2018. Combinatorial approaches to viral attenuation. mSystems 3:e00046-18. https://doi.org/10.1128/mSystems.00046-18.

  1. Address correspondence to Claus O. Wilke, wilke{at}austin.utexas.edu.
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Combinatorial Approaches to Viral Attenuation
Matthew L. Paff, Benjamin R. Jack, Bartram L. Smith, James J. Bull, Claus O. Wilke
mSystems Jul 2018, 3 (4) e00046-18; DOI: 10.1128/mSystems.00046-18

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Combinatorial Approaches to Viral Attenuation
Matthew L. Paff, Benjamin R. Jack, Bartram L. Smith, James J. Bull, Claus O. Wilke
mSystems Jul 2018, 3 (4) e00046-18; DOI: 10.1128/mSystems.00046-18
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KEYWORDS

bacteriophages
codon deoptimization
promoter knockout
viral attenuation

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