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Archive

May/June 2018; Volume 3,Issue 3

Editorial

  • Earth Microbiome Project and Global Systems Biology
    Editorial
    Earth Microbiome Project and Global Systems Biology
    Jack A. Gilbert, Janet K. Jansson, Rob Knight
    10 Apr 2018

Commentary

  • Crowdsourcing Our National Gut
    Commentary | Host-Microbe Biology
    Crowdsourcing Our National Gut

    The microbes of the human intestinal tract play a profound role in our health. The complex interactions between our gut microbial communities and the external environment, and the resulting functional consequences, can be difficult to disentangle.

    Laura E. Grieneisen, Ran Blekhman
    15 May 2018

Minireview

  • From Network Analysis to Functional Metabolic Modeling of the Human Gut Microbiota
    Minireview | Novel Systems Biology Techniques
    From Network Analysis to Functional Metabolic Modeling of the Human Gut Microbiota

    An important hallmark of the human gut microbiota is its species diversity and complexity. Various diseases have been associated with a decreased diversity leading to reduced metabolic functionalities.

    Eugen Bauer, Ines Thiele
    27 Mar 2018

Observation

  • Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome
    Observation | Host-Microbe Biology
    Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome

    Intestinal dysbiosis mediates various cardiovascular diseases comorbid with OSA. To understand the role of dysbiosis in cardiovascular and metabolic disease caused by OSA, we systematically study the effect of intermittent hypoxic/hypercapnic stress (IHH, mimicking OSA) on gut microbes in an animal model. We take advantage of a longitudinal study design and paired omics to investigate the microbial and molecular dynamics in the gut to...

    Anupriya Tripathi, Alexey V. Melnik, Jin Xue, Orit Poulsen, Michael J. Meehan, Gregory Humphrey, Lingjing Jiang, Gail Ackermann, Daniel McDonald, Dan Zhou, Rob Knight, Pieter C. Dorrestein, Gabriel G. Haddad
    5 Jun 2018

Methods and Protocols

  • SHI7 Is a Self-Learning Pipeline for Multipurpose Short-Read DNA Quality Control
    Methods and Protocols | Novel Systems Biology Techniques
    SHI7 Is a Self-Learning Pipeline for Multipurpose Short-Read DNA Quality Control

    Quality control of high-throughput DNA sequencing data is an important but sometimes laborious task requiring background knowledge of the sequencing protocol used (such as adaptor type, sequencing technology, insert size/stitchability, paired-endedness, etc.). Quality control protocols typically require applying this background knowledge to selecting and executing numerous quality control steps with the appropriate parameters, which is...

    Gabriel A. Al-Ghalith, Benjamin Hillmann, Kaiwei Ang, Robin Shields-Cutler, Dan Knights
    24 Apr 2018

Research Articles

  • Fecal Microbiota Transplantation in Gestating Sows and Neonatal Offspring Alters Lifetime Intestinal Microbiota and Growth in Offspring
    Editor's Pick Research Article | Host-Microbe Biology
    Fecal Microbiota Transplantation in Gestating Sows and Neonatal Offspring Alters Lifetime Intestinal Microbiota and Growth in Offspring

    Here, for the first time, we investigate FMT as a novel strategy to modulate the porcine intestinal microbiota in an attempt to improve FE in pigs. However, reprogramming the maternal and/or offspring microbiome by using fecal transplants derived from highly feed-efficient pigs did not recapitulate the highly efficient phenotype in the offspring and, in fact, had detrimental effects on lifetime growth. Although these findings may not be...

    Ursula M. McCormack, Tânia Curião, Toby Wilkinson, Barbara U. Metzler-Zebeli, Henry Reyer, Tomas Ryan, Julia A. Calderon-Diaz, Fiona Crispie, Paul D. Cotter, Christopher J. Creevey, Gillian E. Gardiner, Peadar G. Lawlor
    13 Mar 2018
  • Metagenomics Reveals the Influence of Land Use and Rain on the Benthic Microbial Communities in a Tropical Urban Waterway
    Editor's Pick Research Article | Applied and Environmental Science
    Metagenomics Reveals the Influence of Land Use and Rain on the Benthic Microbial Communities in a Tropical Urban Waterway

    Unravelling the microbial metagenomes of urban waterway sediments suggest that well-managed urban waterways have the potential to support diverse sedimentary microbial communities, similar to those of undisturbed natural freshwaters. Despite the fact that these urban waterways are well managed, our study shows that environmental pressures from land use and rain perturbations play a role in shaping the structure and functions of...

    Gourvendu Saxena, Suparna Mitra, Ezequiel M. Marzinelli, Chao Xie, Toh Jun Wei, Peter D. Steinberg, Rohan B. H. Williams, Staffan Kjelleberg, Federico M. Lauro, Sanjay Swarup
    5 Jun 2018
  • Development of the Human Mycobiome over the First Month of Life and across Body Sites
    Research Article | Clinical Science and Epidemiology
    Development of the Human Mycobiome over the First Month of Life and across Body Sites

    Humans are colonized by diverse fungi (mycobiome), which have received much less study to date than colonizing bacteria. We know very little about the succession of fungal colonization in early life and whether it may relate to long-term health. To better understand fungal colonization and its sources, we studied the skin, oral, and anal mycobiomes of healthy term infants and the vaginal and anal mycobiomes of their mothers. Generally,...

    Tonya L. Ward, Maria Gloria Dominguez-Bello, Tim Heisel, Gabriel Al-Ghalith, Dan Knights, Cheryl A. Gale
    6 Mar 2018
  • Genome-Scale, Constraint-Based Modeling of Nitrogen Oxide Fluxes during Coculture of <em>Nitrosomonas europaea</em> and <em>Nitrobacter winogradskyi</em>
    Editor's Pick Research Article | Novel Systems Biology Techniques
    Genome-Scale, Constraint-Based Modeling of Nitrogen Oxide Fluxes during Coculture of Nitrosomonas europaea and Nitrobacter winogradskyi

    Modern agriculture is sustained by application of inorganic nitrogen (N) fertilizer in the form of ammonium (NH4+). Up to 60% of NH4+-based fertilizer can be lost through leaching of nitrifier-derived nitrate (NO3−), and through the emission of N oxide gases (i.e., nitric oxide [NO], N dioxide [NO2], and nitrous oxide [N2O] gases), the latter being a...

    Brett L. Mellbye, Andrew T. Giguere, Ganti S. Murthy, Peter J. Bottomley, Luis A. Sayavedra-Soto, Frank W. R. Chaplen
    13 Mar 2018
  • Modeling the <em>Pseudomonas</em> Sulfur Regulome by Quantifying the Storage and Communication of Information
    Research Article | Novel Systems Biology Techniques
    Modeling the Pseudomonas Sulfur Regulome by Quantifying the Storage and Communication of Information

    Bacteria sense and respond to their environments using a sophisticated array of sensors and regulatory networks to optimize their fitness and survival in a constantly changing environment. Understanding how these regulatory and sensory networks work will provide the capacity to predict bacterial behaviors and, potentially, to manipulate their interactions with an environment or host. Leveraging the information theory provides useful...

    Peter E. Larsen, Sarah Zerbs, Philip D. Laible, Frank R. Collart, Peter Korajczyk, Yang Dai, Philippe Noirot
    19 Jun 2018
  • Developing a <em>Bacteroides</em> System for Function-Based Screening of DNA from the Human Gut Microbiome
    Research Article | Novel Systems Biology Techniques
    Developing a Bacteroides System for Function-Based Screening of DNA from the Human Gut Microbiome

    Human gut microbiome research has been supported by advances in DNA sequencing that make it possible to obtain gigabases of sequence data from metagenomes but is limited by a lack of knowledge of gene function that leads to incomplete annotation of these data sets. There is a need for the development of methods that can provide experimental data regarding microbial gene function. Functional metagenomics is one such method, but...

    Kathy N. Lam, Eric C. Martens, Trevor C. Charles
    27 Mar 2018
  • Inferring the Minimal Genome of <em>Mesoplasma florum</em> by Comparative Genomics and Transposon Mutagenesis
    Research Article | Molecular Biology and Physiology
    Inferring the Minimal Genome of Mesoplasma florum by Comparative Genomics and Transposon Mutagenesis

    The last years have witnessed the development of whole-genome cloning and transplantation methods and the complete synthesis of entire chromosomes. Recently, the first minimal cell, Mycoplasma mycoides JCVI-syn3.0, was created. Despite these milestone achievements, several questions remain to be answered. For example, is the composition of minimal genomes virtually...

    Vincent Baby, Jean-Christophe Lachance, Jules Gagnon, Jean-François Lucier, Dominick Matteau, Tom Knight, Sébastien Rodrigue
    10 Apr 2018
  • Interaction between Host MicroRNAs and the Gut Microbiota in Colorectal Cancer
    Editor's Pick Research Article | Host-Microbe Biology
    Interaction between Host MicroRNAs and the Gut Microbiota in Colorectal Cancer

    Recent studies have found an association between colorectal cancer (CRC) and the gut microbiota. One potential mechanism by which the microbiota can influence host physiology is through affecting gene expression in host cells. MicroRNAs (miRNAs) are small noncoding RNA molecules that can regulate gene expression and have important roles in cancer development. Here, we investigated the link between the gut microbiota and the expression...

    Ce Yuan, Michael B. Burns, Subbaya Subramanian, Ran Blekhman
    15 May 2018
  • <em>luxR</em> Homolog-Linked Biosynthetic Gene Clusters in <em>Proteobacteria</em>
    Research Article | Ecological and Evolutionary Science
    luxR Homolog-Linked Biosynthetic Gene Clusters in Proteobacteria

    Bacteria biosynthesize specialized metabolites with a variety of ecological functions, including defense against other microbes. Genes that code for specialized metabolite biosynthetic enzymes are frequently clustered together. These BGCs are often regulated by a transcription factor encoded within the cluster itself. These pathway-specific regulators respond to a signal or indirectly through other means of environmental sensing. Many...

    Carolyn A. Brotherton, Marnix H. Medema, E. Peter Greenberg
    27 Mar 2018
  • Interleukin 1α-Deficient Mice Have an Altered Gut Microbiota Leading to Protection from Dextran Sodium Sulfate-Induced Colitis
    Editor's Pick Research Article | Host-Microbe Biology
    Interleukin 1α-Deficient Mice Have an Altered Gut Microbiota Leading to Protection from Dextran Sodium Sulfate-Induced Colitis

    Here, we show a connection between IL-1α expression, microbiota composition, and clinical outcomes of DSS-induced colitis. Specifically, we show that the mild colitis symptoms seen in IL-1α-deficient mice following administration of DSS are correlated with the unique gut microbiota compositions of the mice. However, when these mice are exposed to WT microbiota by cohousing, their gut microbiota composition returns to resemble that of WT...

    Moran Nunberg, Nir Werbner, Hadar Neuman, Marina Bersudsky, Alex Braiman, Moshe Ben-Shoshan, Meirav Ben Izhak, Yoram Louzoun, Ron N. Apte, Elena Voronov, Omry Koren
    8 May 2018
  • KatharoSeq Enables High-Throughput Microbiome Analysis from Low-Biomass Samples
    Research Article | Novel Systems Biology Techniques
    KatharoSeq Enables High-Throughput Microbiome Analysis from Low-Biomass Samples

    Various indoor, outdoor, and host-associated environments contain small quantities of microbial biomass and represent a niche that is often understudied because of technical constraints. Many studies that attempt to evaluate these low-biomass microbiome samples are riddled with erroneous results that are typically false positive signals obtained during the sampling process. We have investigated various low-biomass kits and methods to...

    Jeremiah J. Minich, Qiyun Zhu, Stefan Janssen, Ryan Hendrickson, Amnon Amir, Russ Vetter, John Hyde, Megan M. Doty, Kristina Stillwell, James Benardini, Jae H. Kim, Eric E. Allen, Kasthuri Venkateswaran, Rob Knight
    13 Mar 2018
  • Evolution of Bacterial Global Modulators: Role of a Novel H-NS Paralogue in the Enteroaggregative <em>Escherichia coli</em> Strain 042
    Research Article | Host-Microbe Biology
    Evolution of Bacterial Global Modulators: Role of a Novel H-NS Paralogue in the Enteroaggregative Escherichia coli Strain 042

    Global regulators such as H-NS play key relevant roles enabling bacterial cells to adapt to a changing environment. H-NS modulates both core and horizontally transferred (HGT) genes, but the mechanism by which H-NS can differentially regulate these genes remains to be elucidated. There are several instances of bacterial cells carrying genes that encode homologues of the global regulators. The question is what the roles of these proteins...

    A. Prieto, M. Bernabeu, S. Aznar, S. Ruiz-Cruz, A. Bravo, M. H. Queiroz, A. Juárez
    20 Mar 2018
  • Asymptomatic Intestinal Colonization with Protist <em>Blastocystis</em> Is Strongly Associated with Distinct Microbiome Ecological Patterns
    Research Article | Host-Microbe Biology
    Asymptomatic Intestinal Colonization with Protist Blastocystis Is Strongly Associated with Distinct Microbiome Ecological Patterns

    Given the results of our study and other reports of the effects of the most common human gut protist on the diversity and composition of the bacterial microbiome, Blastocystis and, possibly, other gut protists should be studied as ecosystem engineers that drive community diversity and composition.

    M. E. Nieves-Ramírez, O. Partida-Rodríguez, I. Laforest-Lapointe, L. A. Reynolds, E. M. Brown, A. Valdez-Salazar, P. Morán-Silva, L. Rojas-Velázquez, E. Morien, L. W. Parfrey, M. Jin, J. Walter, J. Torres, M. C. Arrieta, C. Ximénez-García, B. B. Finlay
    26 Jun 2018
  • Genome Reduction in <em>Psychromonas</em> Species within the Gut of an Amphipod from the Ocean’s Deepest Point
    Editor's Pick Research Article | Host-Microbe Biology
    Genome Reduction in Psychromonas Species within the Gut of an Amphipod from the Ocean’s Deepest Point

    As a unique but poorly investigated habitat within marine ecosystems, hadal trenches have received interest in recent years. This study explores the gut microbial composition and function in hadal amphipods, which are among the dominant carrion feeders in hadal habitats. Further analyses of a dominant strain revealed genomic features that may contribute to its adaptation to the amphipod gut environment. Our findings provide new insights...

    Weipeng Zhang, Ren-Mao Tian, Jin Sun, Salim Bougouffa, Wei Ding, Lin Cai, Yi Lan, Haoya Tong, Yongxin Li, Alan J. Jamieson, Vladimir B. Bajic, Jeffrey C. Drazen, Douglas Bartlett, Pei-Yuan Qian
    10 Apr 2018
  • Identification of Pathogenicity-Associated Loci in <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> from Hospitalized Patients
    Research Article | Host-Microbe Biology
    Identification of Pathogenicity-Associated Loci in Klebsiella pneumoniae from Hospitalized Patients

    Klebsiella pneumoniae is a common cause of infections in the health care setting. This work supports a paradigm for K. pneumoniae pathogenesis where the accessory genome, composed of genes present in some but not all isolates, influences whether a strain causes infection or asymptomatic colonization...

    Rebekah M. Martin, Jie Cao, Weisheng Wu, Lili Zhao, David M. Manthei, Ali Pirani, Evan Snitkin, Preeti N. Malani, Krishna Rao, Michael A. Bachman
    26 Jun 2018
  • Characterization of Wild and Captive Baboon Gut Microbiota and Their Antibiotic Resistomes
    Editor's Pick Research Article | Ecological and Evolutionary Science
    Characterization of Wild and Captive Baboon Gut Microbiota and Their Antibiotic Resistomes

    Antibiotic exposure results in acute and persistent shifts in the composition and function of microbial communities associated with vertebrate hosts. However, little is known about the state of these communities in the era before the widespread introduction of antibiotics into clinical and agricultural practice. We characterized the fecal microbiota and antibiotic resistomes of wild and captive baboon populations to understand the...

    Pablo Tsukayama, Manish Boolchandani, Sanket Patel, Erica C. Pehrsson, Molly K. Gibson, Kenneth L. Chiou, Clifford J. Jolly, Jeffrey Rogers, Jane E. Phillips-Conroy, Gautam Dantas
    26 Jun 2018
  • Genomics of the Uncultivated, Periodontitis-Associated Bacterium <em>Tannerella</em> sp. BU045 (Oral Taxon 808)
    Research Article | Host-Microbe Biology
    Genomics of the Uncultivated, Periodontitis-Associated Bacterium Tannerella sp. BU045 (Oral Taxon 808)

    Periodontitis (gum disease) affects 47% of adults over 30 in the United States (P. I. Eke, B. A. Dye, L. Wei, G. O. Thornton-Evans, R. J. Genco, et al., J Dent Res 91:914–920, 2012), and it cost between $39 and $396 billion worldwide in 2015 (A. J. Righolt, M. Jevdjevic, W. Marcenes, and S. Listl, J Dent Res, 17 January 2018, https://doi.org/10.1177/0022034517750572). Many bacteria...

    Clifford J. Beall, Alisha G. Campbell, Ann L. Griffen, Mircea Podar, Eugene J. Leys
    5 Jun 2018
  • Phylogenetic Placement of Exact Amplicon Sequences Improves Associations with Clinical Information
    Research Article | Ecological and Evolutionary Science
    Phylogenetic Placement of Exact Amplicon Sequences Improves Associations with Clinical Information

    The move from OTU-based to sOTU-based analysis, while providing additional resolution, also introduces computational challenges. We demonstrate that one popular method of dealing with sOTUs (building a de novo tree from the short sequences) can provide incorrect results in human gut metagenomic studies and show that phylogenetic placement of the new sequences with SEPP resolves this problem while also yielding other benefits...

    Stefan Janssen, Daniel McDonald, Antonio Gonzalez, Jose A. Navas-Molina, Lingjing Jiang, Zhenjiang Zech Xu, Kevin Winker, Deborah M. Kado, Eric Orwoll, Mark Manary, Siavash Mirarab, Rob Knight
    17 Apr 2018
  • Taxon Disappearance from Microbiome Analysis Reinforces the Value of Mock Communities as a Standard in Every Sequencing Run
    Research Article | Applied and Environmental Science
    Taxon Disappearance from Microbiome Analysis Reinforces the Value of Mock Communities as a Standard in Every Sequencing Run

    Despite the routine use of standards and blanks in virtually all chemical or physical assays and most biological studies (a kind of “control”), microbiome analysis has traditionally lacked such standards. Here we show that unexpected problems of unknown origin can occur in such sequencing runs and yield completely incorrect results that would not necessarily be detected without the use of standards. Assuming that the microbiome...

    Yi-Chun Yeh, David M. Needham, Ella T. Sieradzki, Jed A. Fuhrman
    3 Apr 2018
  • Quantifying the Evolutionary Conservation of Genes Encoding Multidrug Efflux Pumps in the ESKAPE Pathogens To Identify Antimicrobial Drug Targets
    Research Article | Ecological and Evolutionary Science
    Quantifying the Evolutionary Conservation of Genes Encoding Multidrug Efflux Pumps in the ESKAPE Pathogens To Identify Antimicrobial Drug Targets

    Increasing rates of antibiotic-resistant bacterial infection are one of the most pressing contemporary global health concerns. The ESKAPE pathogen group represents the leading cause of these infections, and upregulation of efflux pump expression is a significant mechanism of resistance in these pathogens. This has resulted in substantial interest in the development of efflux pump inhibitors to combat antibiotic-resistant infections;...

    Lauren E. Brooks, Sabah Ul-Hasan, Benjamin K. Chan, Mark J. Sistrom
    17 Apr 2018
  • Viromic Analysis of Wastewater Input to a River Catchment Reveals a Diverse Assemblage of RNA Viruses
    Research Article | Applied and Environmental Science
    Viromic Analysis of Wastewater Input to a River Catchment Reveals a Diverse Assemblage of RNA Viruses

    Enteric viruses cause gastrointestinal illness and are commonly transmitted through the fecal-oral route. When wastewater is released into river systems, these viruses can contaminate the environment. Our results show that we can use viromics to find the range of potentially pathogenic viruses that are present in the environment and identify prevalent genotypes. The ultimate goal is to trace the fate of these pathogenic viruses from...

    Evelien M. Adriaenssens, Kata Farkas, Christian Harrison, David L. Jones, Heather E. Allison, Alan J. McCarthy
    22 May 2018
  • American Gut: an Open Platform for Citizen Science Microbiome Research
    Research Article | Host-Microbe Biology
    American Gut: an Open Platform for Citizen Science Microbiome Research

    We show that a citizen science, self-selected cohort shipping samples through the mail at room temperature recaptures many known microbiome results from clinically collected cohorts and reveals new ones. Of particular interest is integrating n = 1 study data with the population data, showing that the extent of microbiome change after events such as surgery can exceed differences between distinct environmental biomes, and the...

    Daniel McDonald, Embriette Hyde, Justine W. Debelius, James T. Morton, Antonio Gonzalez, Gail Ackermann, Alexander A. Aksenov, Bahar Behsaz, Caitriona Brennan, Yingfeng Chen, Lindsay DeRight Goldasich, Pieter C. Dorrestein, Robert R. Dunn, Ashkaan K. Fahimipour, James Gaffney, Jack A. Gilbert, Grant Gogul, Jessica L. Green, Philip Hugenholtz, Greg Humphrey, Curtis Huttenhower, Matthew A. Jackson, Stefan Janssen, Dilip V. Jeste, Lingjing Jiang, Scott T. Kelley, Dan Knights, Tomasz Kosciolek, Joshua Ladau, Jeff Leach, Clarisse Marotz, Dmitry Meleshko, Alexey V. Melnik, Jessica L. Metcalf, Hosein Mohimani, Emmanuel Montassier, Jose Navas-Molina, Tanya T. Nguyen, Shyamal Peddada, Pavel Pevzner, Katherine S. Pollard, Gholamali Rahnavard, Adam Robbins-Pianka, Naseer Sangwan, Joshua Shorenstein, Larry Smarr, Se Jin Song, Timothy Spector, Austin D. Swafford, Varykina G. Thackray, Luke R. Thompson, Anupriya Tripathi, Yoshiki Vázquez-Baeza, Alison Vrbanac, Paul Wischmeyer, Elaine Wolfe, Qiyun Zhu, The American Gut Consortium, Rob Knight
    15 May 2018
  • Nonpareil 3: Fast Estimation of Metagenomic Coverage and Sequence Diversity
    Research Article | Novel Systems Biology Techniques
    Nonpareil 3: Fast Estimation of Metagenomic Coverage and Sequence Diversity

    Estimation of the coverage provided by a metagenomic data set, i.e., what fraction of the microbial community was sampled by DNA sequencing, represents an essential first step of every culture-independent genomic study that aims to robustly assess the sequence diversity present in a sample. However, estimation of coverage remains elusive because of several technical limitations associated with high computational requirements and...

    Luis M. Rodriguez-R, Santosh Gunturu, James M. Tiedje, James R. Cole, Konstantinos T. Konstantinidis
    10 Apr 2018
  • Heterotroph Interactions Alter <em>Prochlorococcus</em> Transcriptome Dynamics during Extended Periods of Darkness
    Editor's Pick Research Article | Molecular Biology and Physiology
    Heterotroph Interactions Alter Prochlorococcus Transcriptome Dynamics during Extended Periods of Darkness

    Prochlorococcus is the most abundant photosynthetic organism on the planet. These cells play a central role in the physiology of surrounding heterotrophs by supplying them with fixed organic carbon. It is becoming increasingly clear, however, that interactions with heterotrophs can affect autotrophs as well. Here we show that such interactions have a marked impact on the response of Prochlorococcus to the stress of...

    Steven J. Biller, Allison Coe, Sara E. Roggensack, Sallie W. Chisholm
    29 May 2018
  • A Prospective Metagenomic and Metabolomic Analysis of the Impact of Exercise and/or Whey Protein Supplementation on the Gut Microbiome of Sedentary Adults
    Research Article | Host-Microbe Biology
    A Prospective Metagenomic and Metabolomic Analysis of the Impact of Exercise and/or Whey Protein Supplementation on the Gut Microbiome of Sedentary Adults

    The gut microbiota of humans is a critical component of functional development and subsequent health. It is important to understand the lifestyle and dietary factors that affect the gut microbiome and what impact these factors may have. Animal studies suggest that exercise can directly affect the gut microbiota, and elite athletes demonstrate unique beneficial and diverse gut microbiome characteristics. These characteristics are...

    Owen Cronin, Wiley Barton, Peter Skuse, Nicholas C. Penney, Isabel Garcia-Perez, Eileen F. Murphy, Trevor Woods, Helena Nugent, Aine Fanning, Silvia Melgar, Eanna C. Falvey, Elaine Holmes, Paul D. Cotter, Orla O’Sullivan, Michael G. Molloy, Fergus Shanahan
    24 Apr 2018
  • Environmental Sources of Bacteria Differentially Influence Host-Associated Microbial Dynamics
    Research Article | Host-Microbe Biology
    Environmental Sources of Bacteria Differentially Influence Host-Associated Microbial Dynamics

    These results provide valuable insights into the ecological influence of exogenous microbial exposure, as well as laying the foundation for improving aquarium management practices. By comparing data for dolphins from aquaria that use natural versus artificial seawater, we demonstrate the potential influence of aquarium water disinfection procedures on dolphin microbial dynamics.

    Cesar Cardona, Simon Lax, Peter Larsen, Brent Stephens, Jarrad Hampton-Marcell, Christian F. Edwardson, Chris Henry, Bill Van Bonn, Jack A. Gilbert
    29 May 2018
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mSystems: 3 (3)

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volume 3, issue 3
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