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Special Issue Perspective | Ecological and Evolutionary Science

In Search of Model Ecological Systems for Understanding Specialized Metabolism

Rita C. Pessotti, Bridget L. Hansen, Matthew F. Traxler
Rita C. Pessotti
aDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA
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Bridget L. Hansen
aDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA
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Matthew F. Traxler
aDepartment of Plant and Microbial Biology, University of California, Berkeley, California, USA
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DOI: 10.1128/mSystems.00175-17
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ABSTRACT

Microbes occupy diverse habitats, forming interconnected, dynamic communities. Elucidating the principles of microbial community function is a grand challenge for microbiology, and it will entail experiments that engage microbiomes across multiple levels of complexity. For example, community-level hypotheses often require testing at the mechanistic and/or genetic levels, while mechanistic relationships require community-level evaluation to understand their importance in context. In this Perspective, we articulate the need for model microbiome systems that enable experimentation in both community and reductionist frameworks, with an emphasis on understanding the role of specialized metabolites in microbial communities. We consider essential criteria for developing such model microbiome systems and discuss potential future models that address the ecology of specialized metabolism.

mSystems® vol. 3, no. 2, is a special issue sponsored by Janssen Human Microbiome Institute (JHMI).

  • Copyright © 2018 Pessotti et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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In Search of Model Ecological Systems for Understanding Specialized Metabolism
Rita C. Pessotti, Bridget L. Hansen, Matthew F. Traxler
mSystems Mar 2018, 3 (2) e00175-17; DOI: 10.1128/mSystems.00175-17

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In Search of Model Ecological Systems for Understanding Specialized Metabolism
Rita C. Pessotti, Bridget L. Hansen, Matthew F. Traxler
mSystems Mar 2018, 3 (2) e00175-17; DOI: 10.1128/mSystems.00175-17
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  • Top
  • Article
    • ABSTRACT
    • MICROBIOMES AND SPECIALIZED METABOLISM
    • CRITERIA FOR IDEAL MODEL ECOLOGICAL SYSTEMS
    • POTENTIAL MODEL SYSTEMS AND THEIR ANALYSIS
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
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KEYWORDS

chemical ecology
interspecies interactions
microbial ecology
microbiome
model systems
specialized metabolism

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