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Research Article | Novel Systems Biology Techniques

Discrete False-Discovery Rate Improves Identification of Differentially Abundant Microbes

Lingjing Jiang, Amnon Amir, James T. Morton, Ruth Heller, Ery Arias-Castro, Rob Knight
Josh D. Neufeld, Editor
Lingjing Jiang
a Department of Pediatrics, University of California San Diego, La Jolla, California, USA
b Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA
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Amnon Amir
a Department of Pediatrics, University of California San Diego, La Jolla, California, USA
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James T. Morton
a Department of Pediatrics, University of California San Diego, La Jolla, California, USA
c Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, USA
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Ruth Heller
d Department of Statistics and Operations Research, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel
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Ery Arias-Castro
e Department of Mathematics, University of California San Diego, La Jolla, California, USA
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Rob Knight
a Department of Pediatrics, University of California San Diego, La Jolla, California, USA
c Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, USA
f Center for Microbiome Innovation, University of California San Diego, La Jolla, California, USA
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Josh D. Neufeld
University of Waterloo
Roles: Editor
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DOI: 10.1128/mSystems.00092-17
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Article Information

DOI 
https://doi.org/10.1128/mSystems.00092-17
PubMed 
29181446

Published By 
American Society for Microbiology Journals
History 
  • Received July 25, 2017
  • Accepted October 29, 2017
  • Published online November 21, 2017.

Copyright & Usage 
Copyright © 2017 Jiang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license .
Editors and / or Reviewers 
  • Josh D. Neufeld, Editor, University of Waterloo

Author Information

  1. Lingjing Jianga,b,
  2. Amnon Amira,
  3. James T. Mortona,c,
  4. Ruth Hellerd,
  5. Ery Arias-Castroe and
  6. Rob Knighta,c,f
  1. a Department of Pediatrics, University of California San Diego, La Jolla, California, USA
  2. b Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA
  3. c Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, USA
  4. d Department of Statistics and Operations Research, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel
  5. e Department of Mathematics, University of California San Diego, La Jolla, California, USA
  6. f Center for Microbiome Innovation, University of California San Diego, La Jolla, California, USA
  • Address correspondence to Rob Knight, robknight{at}ucsd.edu.
  • L.J. and A.A. contributed equally to this article.

  • Citation Jiang L, Amir A, Morton JT, Heller R, Arias-Castro E, Knight R. 2017. Discrete false-discovery rate improves identification of differentially abundant microbes. mSystems 2:e00092-17. https://doi.org/10.1128/mSystems.00092-17 .

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Discrete False-Discovery Rate Improves Identification of Differentially Abundant Microbes
Lingjing Jiang, Amnon Amir, James T. Morton, Ruth Heller, Ery Arias-Castro, Rob Knight
mSystems Nov 2017, 2 (6) e00092-17; DOI: 10.1128/mSystems.00092-17

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Discrete False-Discovery Rate Improves Identification of Differentially Abundant Microbes
Lingjing Jiang, Amnon Amir, James T. Morton, Ruth Heller, Ery Arias-Castro, Rob Knight
mSystems Nov 2017, 2 (6) e00092-17; DOI: 10.1128/mSystems.00092-17
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KEYWORDS

differential abundance
discrete test statistics
FDR
high dimension
microbiome
multiple comparison
multiple testing
sparse
statistics

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