Host-Microbe Biology
Research Article | Host-Microbe BiologyThe Oral and Skin Microbiomes of Captive Komodo Dragons Are Significantly Shared with Their Habitat
Editor's Pick Research Article | Host-Microbe BiologyIdentification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter
Research Article | Host-Microbe BiologyA Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus DiseaseMaking the most of “big data” is one of the core challenges of current biology. There is a large array of heterogeneous data sets of host gene responses to infection, but these data sets do not inform us about gene function and require specialized skill sets and training for their utilization. Here we describe an approach that combines and simplifies these data sets, distilling this information into a single list of genes commonly...
Editor's Pick Research Article | Host-Microbe BiologyIs the Evolution of Salmonella enterica subsp. enterica Linked to Restriction-Modification Systems?The evolution of bacterial pathogens, their plasticity and ability to rapidly change and adapt to new surroundings are crucial for understanding the epidemiology and public health. With the application of genomics, it became clear that horizontal gene transfer played a key role in evolution. To understand the evolution and diversification of pathogens, we need to understand the processes that drive the horizontal gene transfer....
Editor's Pick Perspective | Host-Microbe BiologyGetting the Hologenome Concept Right: an Eco-Evolutionary Framework for Hosts and Their MicrobiomesGiven the complexity of host-microbiota symbioses, scientists and philosophers are asking questions at new biological levels of hierarchical organization—what is a holobiont and hologenome? When should this vocabulary be applied? Are these concepts a null hypothesis for host-microbe systems or limited to a certain spectrum of symbiotic interactions such as host-microbial coevolution? Critical discourse is necessary in this nascent area...
Editor's Pick Research Article | Host-Microbe BiologyLocal Action with Global Impact: Highly Similar Infection Patterns of Human Viruses and BacteriophagesWhile host-virus interaction interfaces have been previously investigated, relatively little is known about the indirect interactions of pathogen and host proteins required for viral infection and host cell function. Therefore, we investigated the topological relationships of human and bacterial viruses and how they interact with their hosts. We focused on those host proteins that are directly targeted by viruses, those that are...
