Host-Microbe Biology
Editor's Pick Research Article | Host-Microbe BiologyImpaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in MiceOur findings indicate that the gut-liver signaling axis contributes to saccharin/sucralose consumption-induced NAFLD. Supplementation with metformin or fructo-oligosaccharide is a potential therapeutic strategy for NAFLD treatment. In addition, we also developed a new nutritional strategy by using a natural sweetener (neohesperidin dihydrochalcone [NHDC]) as a substitute for NAS and free sugars.
Research Article | Host-Microbe BiologyComparative Fungal Community Analyses Using Metatranscriptomics and Internal Transcribed Spacer Amplicon Sequencing from Norway SpruceA deeper understanding of microbial communities associated with plants is revealing their importance for plant health and productivity. RNA extracted from plant field samples represents the host and other organisms present.
Research Article | Host-Microbe BiologyQuantifying Live Microbial Load in Human Saliva Samples over Time Reveals Stable Composition and Dynamic LoadHuman microbiomes are dynamic ecosystems often composed of hundreds of unique microbial taxa. To detect fluctuations over time in the human oral microbiome, we developed a novel workflow to quantify live microbial cells with flow cytometry in parallel with next-generation sequencing, and applied this method to over 150 unstimulated, timed saliva samples.
Research Article | Host-Microbe BiologyMachine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose RegulationRecent studies have shown a clear link between gut microbiota and type 2 diabetes. However, current results are based on cross-sectional studies that aim to determine the microbial dysbiosis when the disease is already prevalent.
Research Article | Host-Microbe BiologyTemporal Stability and Genetic Diversity of 48-Year-Old T-Series PhagesT-series bacteriophages have been used throughout the world for various molecular biology researches, which were critical for establishing the fundamentals of molecular biology, from the structure of DNA to advanced gene-editing tools. These model bacteriophages help keep research data consistent and comparable between laboratories.
Editor's Pick Research Article | Host-Microbe BiologyGenomic Insights into Adaptations of Trimethylamine-Utilizing Methanogens to Diverse Habitats, Including the Human GutMethanomassiliicoccales are less-known members of the human gut archaeome. Members of this order use methylated amines, including trimethylamine, in methane production.
Research Article | Host-Microbe BiologyHuman Milk-Fed Piglets Have a Distinct Small Intestine and Circulatory Metabolome Profile Relative to That of Milk Formula-Fed PigletsExclusive HM feeding for newborns is recommended at least for the first 6 months of life. However, when breastfeeding is not possible, MF is recommended as a substitute.
Research Article | Host-Microbe BiologyA 16S rRNA Gene and Draft Genome Database for the Murine Oral Bacterial CommunityMouse model studies are frequently used in oral microbiome research, particularly to investigate diseases such as periodontitis and caries, as well as other related systemic diseases. We have reported here the details of the development of a curated reference database to characterize the oral microbial community in laboratory and some wild mice.
Editor's Pick Research Article | Host-Microbe BiologyManipulation of IRE1-Dependent MAPK Signaling by a Vibrio Agonist-Antagonist Effector PairVibrio parahaemolyticus is a seafood-borne pathogen that encodes two type 3 secretion systems (T3SS). The first system, T3SS1, is thought to be maintained in all strains of V. parahaemolyticus to maintain survival in the environment, whereas the second system, T3SS2, is linked to clinical isolates...
Research Article | Host-Microbe BiologyEvaluation of CRISPR Diversity in the Human Skin Microbiome for Personal IdentificationMicrobial community diversity analysis can be utilized to characterize the personal microbiome that varies between individuals. CRISPR sequences, which reflect virome structure, in the human skin environment may be highly personalized similar to the structures of individual viromes.